Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …

A decade of genome sequencing has transformed our understanding of how trypanosomatid
parasites have evolved and provided fresh impetus to explaining the origins of parasitism in …

Chagas disease is a complex illness caused by the protozoan Trypanosoma cruzi
displaying highly diverse clinical outcomes. In this sense, the genome sequence elucidation …

Telomeres prevent chromosome ends from being recognized as double-stranded breaks
(DSBs). Meanwhile, G/C-rich repetitive telomeric DNA is susceptible to attack by DNA …

Background Trypanosoma rangeli is a hemoflagellate protozoan parasite infecting humans
and other wild and domestic mammals across Central and South America. It does not cause …

Trypanosoma cruzi is the causal agent of Chagas' disease which affects millions of people
around the world mostly in Central and South America. T. cruzi expresses a wide variety of …

One of the most powerful drivers of evolutionary change is the process of adaptation and
counter‐adaptation by interacting species (1). The so‐called “arms race” between parasites …

The terminal regions of eukaryotic chromosomes, composed of telomere repeat sequences
and sub-telomeric sequences, represent some of the most variable and rapidly evolving …

Subtelomeres (ST) are chromosome regions that separate telomeres from euchromatin and
play relevant roles in various biological processes of the cell. While their functions are …

R-loops are stable RNA–DNA hybrids that have been implicated in transcription initiation
and termination, as well as in telomere maintenance, chromatin formation, and genome …