Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Abstract Sodium–glucose cotransporter 2 (SGLT2) inhibitors reduce heart failure events by
direct action on the failing heart that is independent of changes in renal tubular function. In …

The ketone bodies beta-hydroxybutyrate and acetoacetate are hepatically produced
metabolites catabolized in extrahepatic organs. Ketone bodies are a critical cardiac fuel and …

Prospective molecular targets and therapeutic applications for ketone body metabolism
have increased exponentially in the past decade. Initially considered to be restricted in …

Background: Experimental evidence suggests a key role of SIRT1 (silent information
regulator 1) in age-and metabolic-related vascular dysfunction. Whether these effects hold …

Abstract The ketone body 3-hydroxybutyrate (3-OHB) increases cardiac output and
myocardial perfusion without affecting blood pressure in humans, but the cardiovascular …

Genome-wide association analyses using high-throughput metabolomics platforms have led
to novel insights into the biology of human metabolism,,,,,–. This detailed knowledge of the …

The goal of this narrative review is to summarize the effects of prolonged fasting on various
metabolic health measures, including body weight, blood pressure, plasma lipids, and …

Many aspects of cell homeostasis and integrity are maintained by the nucleotide-binding
oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 …

Senescence is an inevitable biological process. Disturbances in glucose and lipid
metabolism are essential features of cellular senescence. Given the important roles of these …