Atherosclerosis is a chronic inflammatory vascular disease driven by traditional and
nontraditional risk factors. Genome-wide association combined with clonal lineage tracing …

Atherosclerosis is a chronic inflammatory disease of the arterial wall, characterized by the
formation of plaques containing lipid, connective tissue and immune cells in the intima of …

The gut microbiota is a central regulator of host metabolism. The composition and function of
the gut microbiota is dynamic and affected by diet properties such as the amount and …

Obesity is one of the major health burdens of the 21st century as it contributes to the growing
prevalence of its related comorbidities, including insulin resistance and type 2 diabetes …

Systemic inflammation has been suggested to have a pivotal role in atherothrombosis, but
the factors that trigger systemic inflammation have not been fully elucidated …

Rationale: Atherosclerotic lesions are known for their cellular heterogeneity, yet the
molecular complexity within the cells of human plaques has not been fully assessed …

Inflammation is an important driver of atherosclerosis, the underlying pathology of
cardiovascular diseases. Therefore, therapeutic targeting of inflammatory pathways is …

Atherosclerosis is one type of cardiovascular disease (CVD) in which activation of the
NLRP3 inflammasome and toll-like receptor (TLR) pathways is implicated. One of the most …

Amyloid plaques, mainly composed of abnormally aggregated amyloid β-protein (Aβ) in the
brain parenchyma, and neurofibrillary tangles (NFTs), consisting of hyperphosphorylated tau …

Although diet has long been known to contribute to the pathogenesis of cardiovascular
disease (CVD), research over the past decade has revealed an unexpected interplay …