Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-
containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation …

Influenza viruses are major human pathogens responsible for respiratory diseases affecting
millions of people worldwide and characterized by high morbidity and significant mortality …

Influenza A virus (IVA) has been continuously causing pandemics in several animal hosts
and has become a worldwide public health threat. Currently, antiviral drugs have become …

Introduction: Macromolecular X-ray crystallography has been the primary methodology for
determining the three-dimensional structures of proteins, nucleic acids and viruses …

Covering: 2012 to 2014. Previous review: Nat. Prod. Rep., 2012, 29, 1382 The present
review discusses the isolation, structure determination, synthesis, biosynthesis and …

Introduction: X-ray crystallography plays an important role in structure-based drug design
(SBDD), and accurate analysis of crystal structures of target macromolecules and …

Despite being a common viral disease, influenza has very negative consequences, causing
the death of around half a million people each year. A neuraminidase located on the surface …

Proteolytic cleavage of influenza A virus (IAV) hemagglutinin by host proteases is crucial for
virus infectivity and spread. The transmembrane serine protease TMPRSS2 was previously …

Influenza A virus is the major cause of seasonal or pandemic flu worldwide. Two main
treatment strategies–vaccination and small molecule anti-influenza drugs are currently …

Influenza virus is a pathogen that causes morbidity and mortality worldwide. Whereas
vaccination is important for prevention of disease, given its limitations, antiviral therapy is at …