Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Microenvironment imbalance of spinal cord injury

B Fan, Z Wei, X Yao, G Shi, X Cheng… - Cell …, 2018 - journals.sagepub.com
Spinal cord injury (SCI), for which there currently is no cure, is a heavy burden on patient
physiology and psychology. The microenvironment of the injured spinal cord is complicated …

Transplanting neural progenitor cells to restore connectivity after spinal cord injury

I Fischer, JN Dulin, MA Lane - Nature Reviews Neuroscience, 2020 - nature.com
Spinal cord injury remains a scientific and therapeutic challenge with great cost to
individuals and society. The goal of research in this field is to find a means of restoring lost …

Time is spine: a review of translational advances in spinal cord injury: JNSPG 75th Anniversary Invited Review Article

JH Badhiwala, CS Ahuja, MG Fehlings - Journal of Neurosurgery: Spine, 2018 - thejns.org
Acute traumatic spinal cord injury (SCI) is a devastating event with far-reaching physical,
emotional, and economic consequences for patients, families, and society at large. Timely …

Progress in stem cell therapy for spinal cord injury

L Gao, Y Peng, W Xu, P He, T Li, X Lu… - Stem Cells …, 2020 - Wiley Online Library
Background. Spinal cord injury (SCI) is one of the serious neurological diseases that occur
in young people with high morbidity and disability. However, there is still a lack of effective …

The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury

CS Ahuja, A Mothe, M Khazaei… - Stem cells …, 2020 - academic.oup.com
Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial
costs for millions of individuals and families worldwide. Rapid delivery of specialized …

Crosstalk between stem cell and spinal cord injury: pathophysiology and treatment strategies

A Shao, S Tu, J Lu, J Zhang - Stem cell research & therapy, 2019 - Springer
The injured spinal cord is difficult to repair and regenerate. Traditional treatments are not
effective. Stem cells are a type of cells that have the potential to differentiate into various …

Transplantation of A2 type astrocytes promotes neural repair and remyelination after spinal cord injury

J Chang, Z Qian, B Wang, J Cao, S Zhang… - Cell Communication and …, 2023 - Springer
Background Limited progress in terms of an effective treatment for spinal cord injury (SCI)
emphasizes the urgent need for novel therapies. As a vital central nervous system …

Strategies and prospects of effective neural circuits reconstruction after spinal cord injury

B Yang, F Zhang, F Cheng, L Ying, C Wang, K Shi… - Cell Death & …, 2020 - nature.com
Due to the disconnection of surviving neural elements after spinal cord injury (SCI), such
patients had to suffer irreversible loss of motor or sensory function, and thereafter enormous …

Delving into the recent advancements of spinal cord injury treatment: a review of recent progress

JA Flack, KD Sharma, JY Xie - Neural regeneration research, 2022 - journals.lww.com
Spinal cord injury (SCI) research is a very complex field lending to why reviews of SCI
literatures can be beneficial to current and future researchers. This review focuses on recent …