Ubiquitin ligases: guardians of mammalian development
DA Cruz Walma, Z Chen, AN Bullock… - … Reviews Molecular Cell …, 2022 - nature.com
Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …
located in temporal order, and their function regulated, to orchestrate important steps in cell …
VolcaNoseR is a web app for creating, exploring, labeling and sharing volcano plots
J Goedhart, MS Luijsterburg - Scientific reports, 2020 - nature.com
Comparative genome-and proteome-wide screens yield large amounts of data. To efficiently
present such datasets and to simplify the identification of hits, the results are often presented …
present such datasets and to simplify the identification of hits, the results are often presented …
Tumor-suppressive functions of the aryl hydrocarbon receptor (AhR) and AhR as a therapeutic target in cancer
DJ Elson, SK Kolluri - Biology, 2023 - mdpi.com
Simple Summary Cancer is driven by the excessive activity of growth-promoting genes and
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …
TP53-dependent toxicity of CRISPR/Cas9 cuts is differential across genomic loci and can confound genetic screening
CRISPR/Cas9 gene editing can inactivate genes in a precise manner. This process involves
DNA double-strand breaks (DSB), which may incur a loss of cell fitness. We hypothesize that …
DNA double-strand breaks (DSB), which may incur a loss of cell fitness. We hypothesize that …
ONC201 in combination with paxalisib for the treatment of H3K27-altered diffuse midline glioma
Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the
most lethal of childhood cancers. Palliative radiotherapy is the only established treatment …
most lethal of childhood cancers. Palliative radiotherapy is the only established treatment …
Unbiased interrogation of functional lysine residues in human proteome
Y Bao, Q Pan, P Xu, Z Liu, Z Zhang, Y Liu, Y Xu, Y Yu… - Molecular Cell, 2023 - cell.com
CRISPR screens have empowered the high-throughput dissection of gene functions;
however, more explicit genetic elements, such as codons of amino acids, require thorough …
however, more explicit genetic elements, such as codons of amino acids, require thorough …
Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs
P Xu, Z Liu, Y Liu, H Ma, Y Xu, Y Bao, S Zhu… - Nature …, 2021 - nature.com
Canonical CRISPR–knockout (KO) screens rely on Cas9-induced DNA double-strand
breaks (DSBs) to generate targeted gene KOs. These methodologies may yield distorted …
breaks (DSBs) to generate targeted gene KOs. These methodologies may yield distorted …
Suppression of Ah Receptor (AhR) increases the aggressiveness of TNBC cells and 11-Cl-BBQ-activated AhR inhibits their growth
DJ Elson, BD Nguyen, NA Korjeff, SF Wilferd… - Biochemical …, 2023 - Elsevier
Triple-negative breast cancer (TNBC) represents around 15% of the 2.26 million breast
cancers diagnosed worldwide annually and has the worst outcome. Despite recent …
cancers diagnosed worldwide annually and has the worst outcome. Despite recent …
Somatic structural variant formation is guided by and influences genome architecture
N Sidiropoulos, BR Mardin… - Genome …, 2022 - genome.cshlp.org
The occurrence and formation of genomic structural variants (SVs) is known to be influenced
by the 3D chromatin architecture, but the extent and magnitude have been challenging to …
by the 3D chromatin architecture, but the extent and magnitude have been challenging to …
Regulation of NFκB signalling by ubiquitination: a potential therapeutic target in head and neck squamous cell carcinoma?
EL Morgan, Z Chen, C Van Waes - Cancers, 2020 - mdpi.com
Simple Summary Head and neck cancer is the sixth most common cancer worldwide and
typically caused by smoking and alcohol consumption, or infection with Human …
typically caused by smoking and alcohol consumption, or infection with Human …