Mammalian development demands precision. Millions of molecules must be properly
located in temporal order, and their function regulated, to orchestrate important steps in cell …

Comparative genome-and proteome-wide screens yield large amounts of data. To efficiently
present such datasets and to simplify the identification of hits, the results are often presented …

Simple Summary Cancer is driven by the excessive activity of growth-promoting genes and
deficient activity of the genes that restrain cell growth. Genes that suppress cell growth …

CRISPR/Cas9 gene editing can inactivate genes in a precise manner. This process involves
DNA double-strand breaks (DSB), which may incur a loss of cell fitness. We hypothesize that …

Diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), are the
most lethal of childhood cancers. Palliative radiotherapy is the only established treatment …

CRISPR screens have empowered the high-throughput dissection of gene functions;
however, more explicit genetic elements, such as codons of amino acids, require thorough …

Canonical CRISPR–knockout (KO) screens rely on Cas9-induced DNA double-strand
breaks (DSBs) to generate targeted gene KOs. These methodologies may yield distorted …

Triple-negative breast cancer (TNBC) represents around 15% of the 2.26 million breast
cancers diagnosed worldwide annually and has the worst outcome. Despite recent …

The occurrence and formation of genomic structural variants (SVs) is known to be influenced
by the 3D chromatin architecture, but the extent and magnitude have been challenging to …

Simple Summary Head and neck cancer is the sixth most common cancer worldwide and
typically caused by smoking and alcohol consumption, or infection with Human …