The T-cell receptor (TCR) signalling machinery is central in determining the response of a T
cell (establishing immunity or tolerance) following exposure to antigen. This process is made …

Systems biology is an emerging discipline that combines high-content, multiplexed
measurements with informatic and computational modeling methods to better understand …

T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and
higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) …

T-lymphocyte activation displays a remarkable combination of speed, sensitivity, and
discrimination in response to peptide–major histocompatibility complex (pMHC) ligand …

Cellular decisions are determined by complex molecular interaction networks. Large-scale
signaling networks are currently being reconstructed, but the kinetic parameters and …

The precise timing of signals downstream of the T cell receptor (TCR) is poorly understood.
To address this problem, we prepared major histocompatibility complexes containing an …

T cells discriminate between self and foreign antigenic peptides, displayed on antigen
presenting cell surfaces, via the TCR. While the molecular interactions between TCR and its …

Experimental work has shown that T cells of the immune system rapidly and specifically
respond to antigenic molecules presented on the surface of antigen-presenting-cells and …

T cell receptors (TCRs) play crucial roles in regulating T cell response by rapidly and
accurately recognizing foreign and non-self antigens. The process involves multiple …

We develop a model of tyrosine phosphorylation and activation of the T-cell receptor (TCR)
by localization to regions of close membrane-membrane proximity (close contact) that …