[HTML][HTML] Intracrine androgen biosynthesis, metabolism and action revisited
Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …
The art of measuring steroids: principles and practice of current hormonal steroid analysis
SA Wudy, G Schuler, A Sánchez-Guijo… - The Journal of steroid …, 2018 - Elsevier
Steroids are small and highly important structural or signalling molecules in living organisms
and their metabolism is complex. Due to the multiplicity of enzymes involved there are many …
and their metabolism is complex. Due to the multiplicity of enzymes involved there are many …
Human cytochrome P450 enzymes 5–51 as targets of drugs and natural and environmental compounds: Mechanisms, induction, and inhibition–toxic effects and …
SP Rendic, F Peter Guengerich - Drug metabolism reviews, 2018 - Taylor & Francis
Abstract Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their
roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic …
roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic …
Bystander signaling via oxidative metabolism
The radiation-induced bystander effect (RIBE) is the initiation of biological end points in cells
(bystander cells) that are not directly traversed by an incident-radiation track, but are in close …
(bystander cells) that are not directly traversed by an incident-radiation track, but are in close …
Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H
S Parween, G DiNardo, F Baj, C Zhang… - The Journal of steroid …, 2020 - Elsevier
Abstract Aromatase (CYP19A1) converts androgens into estrogens and is required for
female sexual development and growth and development in both sexes. CYP19A1 is a …
female sexual development and growth and development in both sexes. CYP19A1 is a …
Novel CYP19A1 Mutations Extend the Genotype-Phenotype Correlation and Reveal the Impact on Ovarian Function
VP Praveen, A Ladjouze, KS Sauter… - Journal of the …, 2020 - academic.oup.com
Context The steroidogenic enzyme aromatase (CYP19A1) is required for estrogen
biosynthesis from androgen precursors in the ovary and extragonadal tissues. The role of …
biosynthesis from androgen precursors in the ovary and extragonadal tissues. The role of …
Natural Product Diversification by One‐Step Biocatalysis using Human P450 3A4
ND Fessner, C Grimm, M Srdič, H Weber… - …, 2022 - Wiley Online Library
Efficient synthetic techniques for the diversification of natural products are incremental for
drug discovery processes of the pharmaceutical industry because these complex bioactive …
drug discovery processes of the pharmaceutical industry because these complex bioactive …
Combined chemical and biotechnological production of 20βOH-NorDHCMT, a long-term metabolite of Oral-Turinabol (DHCMT)
J Liu, L Chen, JF Joseph, A Naß, A Stoll… - Journal of inorganic …, 2018 - Elsevier
Anabolic androgenic steroids (AAS) are misused very frequently in sport competitions as
performance enhancing agents. One of the doping compounds that has been detected with …
performance enhancing agents. One of the doping compounds that has been detected with …
Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans
C Khayeka-Wandabwa, X Ma, X Cao, V Nunna… - International …, 2019 - Elsevier
It is thought that autoantibody (aAb) production can be caused by (aberrant) protein
targeting to the plasma surface of cells. We recently demonstrated the presence of the …
targeting to the plasma surface of cells. We recently demonstrated the presence of the …
Gene expression profiling stratifies IDH-wildtype glioblastoma with distinct prognoses
YQ Liu, F Wu, JJ Li, YF Li, X Liu, Z Wang… - Frontiers in …, 2019 - frontiersin.org
Objectives: In the present study, we aimed to determine the candidate genes that may
function as biomarkers to further distinguish patients with isocitrate dehydrogenase (IDH) …
function as biomarkers to further distinguish patients with isocitrate dehydrogenase (IDH) …