[HTML][HTML] Intracrine androgen biosynthesis, metabolism and action revisited

L Schiffer, W Arlt, KH Storbeck - Molecular and cellular endocrinology, 2018 - Elsevier
Androgens play an important role in metabolic homeostasis and reproductive health in both
men and women. Androgen signalling is dependent on androgen receptor activation, mostly …

The art of measuring steroids: principles and practice of current hormonal steroid analysis

SA Wudy, G Schuler, A Sánchez-Guijo… - The Journal of steroid …, 2018 - Elsevier
Steroids are small and highly important structural or signalling molecules in living organisms
and their metabolism is complex. Due to the multiplicity of enzymes involved there are many …

Human cytochrome P450 enzymes 5–51 as targets of drugs and natural and environmental compounds: Mechanisms, induction, and inhibition–toxic effects and …

SP Rendic, F Peter Guengerich - Drug metabolism reviews, 2018 - Taylor & Francis
Abstract Cytochrome P450 (P450, CYP) enzymes have long been of interest due to their
roles in the metabolism of drugs, pesticides, pro-carcinogens, and other xenobiotic …

Bystander signaling via oxidative metabolism

HA Sawal, K Asghar, M Bureik, N Jalal - OncoTargets and therapy, 2017 - Taylor & Francis
The radiation-induced bystander effect (RIBE) is the initiation of biological end points in cells
(bystander cells) that are not directly traversed by an incident-radiation track, but are in close …

Differential effects of variations in human P450 oxidoreductase on the aromatase activity of CYP19A1 polymorphisms R264C and R264H

S Parween, G DiNardo, F Baj, C Zhang… - The Journal of steroid …, 2020 - Elsevier
Abstract Aromatase (CYP19A1) converts androgens into estrogens and is required for
female sexual development and growth and development in both sexes. CYP19A1 is a …

Novel CYP19A1 Mutations Extend the Genotype-Phenotype Correlation and Reveal the Impact on Ovarian Function

VP Praveen, A Ladjouze, KS Sauter… - Journal of the …, 2020 - academic.oup.com
Context The steroidogenic enzyme aromatase (CYP19A1) is required for estrogen
biosynthesis from androgen precursors in the ovary and extragonadal tissues. The role of …

Natural Product Diversification by One‐Step Biocatalysis using Human P450 3A4

ND Fessner, C Grimm, M Srdič, H Weber… - …, 2022 - Wiley Online Library
Efficient synthetic techniques for the diversification of natural products are incremental for
drug discovery processes of the pharmaceutical industry because these complex bioactive …

Combined chemical and biotechnological production of 20βOH-NorDHCMT, a long-term metabolite of Oral-Turinabol (DHCMT)

J Liu, L Chen, JF Joseph, A Naß, A Stoll… - Journal of inorganic …, 2018 - Elsevier
Anabolic androgenic steroids (AAS) are misused very frequently in sport competitions as
performance enhancing agents. One of the doping compounds that has been detected with …

Plasma membrane localization of CYP4Z1 and CYP19A1 and the detection of anti-CYP19A1 autoantibodies in humans

C Khayeka-Wandabwa, X Ma, X Cao, V Nunna… - International …, 2019 - Elsevier
It is thought that autoantibody (aAb) production can be caused by (aberrant) protein
targeting to the plasma surface of cells. We recently demonstrated the presence of the …

Gene expression profiling stratifies IDH-wildtype glioblastoma with distinct prognoses

YQ Liu, F Wu, JJ Li, YF Li, X Liu, Z Wang… - Frontiers in …, 2019 - frontiersin.org
Objectives: In the present study, we aimed to determine the candidate genes that may
function as biomarkers to further distinguish patients with isocitrate dehydrogenase (IDH) …