Acute liver injury (ALI) is a globally important public health issue that, when severe, rapidly
progresses to acute liver failure, seriously compromising the life safety of patients. The …

NLRP3 (NOD-, LRR-, and pyrin domain-containing protein 3) is an intracellular complex that
upon external stimuli or contact with specific ligands, recruits other components, forming the …

The cytoplasmic pattern recognition receptor, absent in melanoma 2 (AIM2), detects
cytosolic DNA, activating the inflammasome and resulting in pro-inflammatory cytokine …

Diacerein is an interleukin (IL)-1β inhibitor approved for osteoarthritis. This study aimed to
investigate the potential anti-fibrotic effect of diacerein against bile duct ligation (BDL) …

Abstract Background Aristolochic acids (AAs), a class of carcinogenic and mutagenic natural
products from Aristolochia and Asarum plants, are well-known to be responsible for inducing …

Background and purpose An overdose of acetaminophen (APAP) causes acute liver
damage and lead to liver failure. Therefore, it is of great clinical significance to find drugs for …

Diclofenac (DF)-induced acute kidney injury (AKI) is characterized by glomerular dysfunction
and acute tubular necrosis. Due to limited treatment approaches, effective and safe drug …

Background The opening of pannexin1 channels is considered as a key event in
inflammation. Pannexin1 channel-mediated release of adenosine triphosphate triggers …

One of the most prevalent chronic conditions affecting older men is benign prostatic
hyperplasia (BPH), causing severe annoyance and embarrassment to patients. The …

APAP (Acetaminophen)-induced hepatic injury is a major public health threat that requires
continuous searching for new effective therapeutics. KSG (Kaempferol-3-sophoroside-7 …