New Insights into Butyrylcholinesterase: Pharmaceutical Applications, Selective Inhibitors and Multitarget-Directed Ligands
T Sun, T Zhen, CH Harakandi, L Wang, H Guo… - European Journal of …, 2024 - Elsevier
Butyrylcholinesterase (BChE), also known as pseudocholinesterase and serum
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …
Exploiting butyrylcholinesterase inhibitors through a combined 3-D pharmacophore modeling, QSAR, molecular docking, and molecular dynamics investigation
S Kumar, A Manoharan, J Jayalakshmi… - RSC …, 2023 - pubs.rsc.org
Alzheimer's disease (AD), a neurodegenerative condition associated with ageing, can occur.
AD gradually impairs memory and cognitive function, which leads to abnormal behavior …
AD gradually impairs memory and cognitive function, which leads to abnormal behavior …
Novel Pyrano[3,2-c]quinoline-1,2,3-triazole Hybrids as Potential Anti-Diabetic Agents: In Vitro α-Glucosidase Inhibition, Kinetic, and Molecular Dynamics Simulation
In this study, a novel series of pyrano [3, 2-c] quinoline-1, 2, 3-triazole hybrids 8a–o were
synthesized and evaluated against the α-glucosidase enzyme. All compounds showed …
synthesized and evaluated against the α-glucosidase enzyme. All compounds showed …
Fused 1, 4‐Dihydropyridines and Their Corresponding Pyridines: Synthesis, Molecular Modeling and Cholinesterase Inhibition
Abstract Novel series of fused 1, 4‐dihydropyridine derivatives were designed and
synthesized. Oxidized to the corresponding pyridines were these dihydropyridines. Both …
synthesized. Oxidized to the corresponding pyridines were these dihydropyridines. Both …
Design, synthesis and biological evaluation of novel tetralone/indanone containing thiosemicarbazone derivatives with selective COX-2 inhibition as anticancer …
ABSTRACT A series of novel tetralone/indanone moiety-bearing thiosemicarbazone
derivatives were synthesized and evaluated for their biological activities. The structural …
derivatives were synthesized and evaluated for their biological activities. The structural …
Photoannulierungen zu Dihydrophenalenonen und 1-Tetralonen
V Schmalz - archiv.ub.uni-marburg.de
Die Reaktionsbedingungen der Photozyklisierung des Cyclopropylesters zum
Dihydrophenalen wurden erfolgreich optimiert und ergaben das Produkt in einer Ausbeute …
Dihydrophenalen wurden erfolgreich optimiert und ergaben das Produkt in einer Ausbeute …