Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review

NAAL Zahrani, RM El-Shishtawy, AM Asiri - European journal of medicinal …, 2020 - Elsevier
The leading cause of several degenerative diseases such as atherosclerosis, cancer, aging,
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …

[HTML][HTML] Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism

B Kalyanaraman - Redox biology, 2017 - Elsevier
This review of the basics of cancer metabolism focuses on exploiting the metabolic
differences between normal and cancer cells. The first part of the review covers the different …

Caloric restriction mimetics: towards a molecular definition

F Madeo, F Pietrocola, T Eisenberg… - Nature reviews Drug …, 2014 - nature.com
Caloric restriction, be it constant or intermittent, is reputed to have health-promoting and
lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic …

A novel triphenylphosphonium carrier to target mitochondria without uncoupling oxidative phosphorylation

CA Kulkarni, BD Fink, BE Gibbs… - Journal of medicinal …, 2021 - ACS Publications
Mitochondrial dysfunction is an underlying pathology in numerous diseases. Delivery of
diagnostic and therapeutic cargo directly into mitochondria is a powerful approach to study …

Application prospects of triphenylphosphine-based mitochondria-targeted cancer therapy

X Cheng, D Feng, J Lv, X Cui, Y Wang, Q Wang… - Cancers, 2023 - mdpi.com
Simple Summary Although there are various treatments for tumors, chemotherapy is still one
of the most dominant and irreplaceable treatment modalities nowadays. Unfortunately …

[HTML][HTML] Exploring the therapeutic potential of mitochondrial uncouplers in cancer

R Shrestha, E Johnson, FL Byrne - Molecular metabolism, 2021 - Elsevier
Background Mitochondrial uncouplers are well-known for their ability to treat a myriad of
metabolic diseases, including obesity and fatty liver diseases. However, for many years now …

Mitochondria-targeted lupane triterpenoid derivatives and their selective apoptosis-inducing anticancer mechanisms

Y Ye, T Zhang, H Yuan, D Li, H Lou… - Journal of Medicinal …, 2017 - ACS Publications
Betulin and betulinic acid have been widely studied for their anticancer activities. However,
their further development is limited due to low bioavailability, poor aqueous solubility, and …

A hypochlorite-activated strategy for realizing fluorescence turn-on, type I and type II ROS-combined photodynamic tumor ablation

T Huang, H Ji, S Yan, Y Zuo, J Li, JWY Lam, C Han… - Biomaterials, 2023 - Elsevier
The combination of cancer cell-activated fluorescence and the advantages of both type I and
type II photodynamic therapy (PDT) capabilities to achieve a synergistic therapeutic effect in …

Gallic acid and gallates in human health and disease: do mitochondria hold the key to success?

RY Kosuru, A Roy, SK Das… - Molecular nutrition & food …, 2018 - Wiley Online Library
Gallic acid and gallate esters are widely used as dietary supplements or additives with
clinical significances. Over the last few decades, a large number of publications have been …

Gallic acid: A dietary polyphenol that exhibits anti-neoplastic activities by modulating multiple oncogenic targets

HS Tuli, H Mistry, G Kaur, D Aggarwal… - Anti-Cancer Agents …, 2022 - ingentaconnect.com
Phytochemicals are being used for thousands of years to prevent dreadful malignancy. Side
effects of existing allopathic treatment have also initiated intense research in the field of …