Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review
The leading cause of several degenerative diseases such as atherosclerosis, cancer, aging,
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …
cardiovascular, and inflammatory diseases is oxidative stress, a consequence of …
[HTML][HTML] Teaching the basics of cancer metabolism: Developing antitumor strategies by exploiting the differences between normal and cancer cell metabolism
B Kalyanaraman - Redox biology, 2017 - Elsevier
This review of the basics of cancer metabolism focuses on exploiting the metabolic
differences between normal and cancer cells. The first part of the review covers the different …
differences between normal and cancer cells. The first part of the review covers the different …
Caloric restriction mimetics: towards a molecular definition
Caloric restriction, be it constant or intermittent, is reputed to have health-promoting and
lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic …
lifespan-extending effects. Caloric restriction mimetics (CRMs) are compounds that mimic …
A novel triphenylphosphonium carrier to target mitochondria without uncoupling oxidative phosphorylation
CA Kulkarni, BD Fink, BE Gibbs… - Journal of medicinal …, 2021 - ACS Publications
Mitochondrial dysfunction is an underlying pathology in numerous diseases. Delivery of
diagnostic and therapeutic cargo directly into mitochondria is a powerful approach to study …
diagnostic and therapeutic cargo directly into mitochondria is a powerful approach to study …
Application prospects of triphenylphosphine-based mitochondria-targeted cancer therapy
X Cheng, D Feng, J Lv, X Cui, Y Wang, Q Wang… - Cancers, 2023 - mdpi.com
Simple Summary Although there are various treatments for tumors, chemotherapy is still one
of the most dominant and irreplaceable treatment modalities nowadays. Unfortunately …
of the most dominant and irreplaceable treatment modalities nowadays. Unfortunately …
[HTML][HTML] Exploring the therapeutic potential of mitochondrial uncouplers in cancer
R Shrestha, E Johnson, FL Byrne - Molecular metabolism, 2021 - Elsevier
Background Mitochondrial uncouplers are well-known for their ability to treat a myriad of
metabolic diseases, including obesity and fatty liver diseases. However, for many years now …
metabolic diseases, including obesity and fatty liver diseases. However, for many years now …
Mitochondria-targeted lupane triterpenoid derivatives and their selective apoptosis-inducing anticancer mechanisms
Y Ye, T Zhang, H Yuan, D Li, H Lou… - Journal of Medicinal …, 2017 - ACS Publications
Betulin and betulinic acid have been widely studied for their anticancer activities. However,
their further development is limited due to low bioavailability, poor aqueous solubility, and …
their further development is limited due to low bioavailability, poor aqueous solubility, and …
A hypochlorite-activated strategy for realizing fluorescence turn-on, type I and type II ROS-combined photodynamic tumor ablation
T Huang, H Ji, S Yan, Y Zuo, J Li, JWY Lam, C Han… - Biomaterials, 2023 - Elsevier
The combination of cancer cell-activated fluorescence and the advantages of both type I and
type II photodynamic therapy (PDT) capabilities to achieve a synergistic therapeutic effect in …
type II photodynamic therapy (PDT) capabilities to achieve a synergistic therapeutic effect in …
Gallic acid and gallates in human health and disease: do mitochondria hold the key to success?
Gallic acid and gallate esters are widely used as dietary supplements or additives with
clinical significances. Over the last few decades, a large number of publications have been …
clinical significances. Over the last few decades, a large number of publications have been …
Gallic acid: A dietary polyphenol that exhibits anti-neoplastic activities by modulating multiple oncogenic targets
Phytochemicals are being used for thousands of years to prevent dreadful malignancy. Side
effects of existing allopathic treatment have also initiated intense research in the field of …
effects of existing allopathic treatment have also initiated intense research in the field of …