The nucleosome, which is the primary building block of chromatin, is not a static structure: It
can adopt alternative conformations. Changes in solution conditions or changes in histone …

Transcription initiation by RNA polymerase II (RNA pol II) requires interaction between cis-
acting promoter elements and trans-acting factors. The eukaryotic promoter consists of core …

Trapoxin is a microbially derived cyclotetrapeptide that inhibits histone deacetylation in vivo
and causes mammalian cells to arrest in the cell cycle. A trapoxin affinity matrix was used to …

Ikaros proteins are required for normal T, B, and NK cell development and are postulated to
activate lymphocyte-specific gene expression. Here we examined Ikaros distribution in the …

Sin3 and Rpd3 negatively regulate a diverse set of yeast genes. A mouse Sin3-related
protein is a transcriptional corepressor, and a human Rpd3 homolog is a histone …

Reversible acetylation of lysines on the amino-terminal tails of nucleosomal histones is
correlated with changes in chromatin structure and transcription. The recent characterization …

Summary The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific
transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated …

A summary of previously defined phenotypes in the yeast Saccharomyces cerevisae is
presented. The purpose of this review is to provide a compendium of phenotypes that can be …

Transcriptional repression, which plays a crucial role in diverse biological processes, is
mediated in part by non-DNA-binding co-repressors. The closely related co-repressor …

Eukaryotic organisms from yeast to human contain a multiprotein complex that includes
Rpd3 histone deacetylase and Sin3 corepressor. The Sin3–Rpd3 complex, when recruited …