Advanced glycation end-products (AGEs) constitute a non-homogenous, chemically diverse
group of compounds formed either exogeneously or endogeneously on the course of …

Many of the ligands for Toll-like receptors (TLRs) are unique to microorganisms, such that
receptor activation unequivocally indicates the presence of something foreign. However, a …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Ferroptosis is a type of regulated necrosis that is triggered by a combination of iron toxicity,
lipid peroxidation, and plasma membrane damage. The upstream inducers of ferroptosis …

Metabolism is an essential part of life that provides energy for cell growth. During metabolic
flux, reactive electrophiles are produced that covalently modify macromolecules, leading to …

Neutrophil extracellular traps (NETs) promote atherosclerosis by inducing proinflammatory
cytokines, but the underlying mechanism remains unknown. NET DNA is immunogenic, but …

The receptor for advanced glycation end-products (RAGE) is a multiligand pattern
recognition receptor implicated in diverse chronic inflammatory states. RAGE binds and …

Neutrophil extracellular traps (NETs) are structures consisting of chromatin and antimicrobial
molecules that are released by neutrophils during a form of regulated cell death called …

Alarmins are preformed, endogenous molecules that can be promptly released to signal cell
or tissue stress or damage. The ubiquitous nuclear molecule high-mobility group box 1 …

Improvements in health care and lifestyle have led to an elevated lifespan and increased
focus on age-associated diseases, such as neurodegeneration, cardiovascular disease …