Toll-like receptor signaling and its role in cell-mediated immunity

T Duan, Y Du, C Xing, HY Wang, RF Wang - Frontiers in Immunology, 2022 - frontiersin.org
Innate immunity is the first defense system against invading pathogens. Toll-like receptors
(TLRs) are well-defined pattern recognition receptors responsible for pathogen recognition …

Toll-like receptors in immunity and inflammatory diseases: Past, present, and future

K Vijay - International immunopharmacology, 2018 - Elsevier
The immune system is a very diverse system of the host that evolved during evolution to
cope with various pathogens present in the vicinity of environmental surroundings inhabited …

Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor

S Balderston, JJ Taulbee, E Celaya, K Fung… - Nature Biomedical …, 2021 - nature.com
Simple and fast methods for the detection of target genes with single-nucleotide specificity
could open up genetic research and diagnostics beyond laboratory settings. We recently …

Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection

JD Simmons, CM Stein, C Seshadri, M Campo… - Nature Reviews …, 2018 - nature.com
Mycobacterium tuberculosis is a leading cause of mortality worldwide and establishes a
long-lived latent infection in a substantial proportion of the human population. Multiple lines …

Toll‐like receptor polymorphism in host immune response to infectious diseases: A review

S Mukherjee, S Huda… - Scandinavian journal of …, 2019 - Wiley Online Library
Immunopolymorphism is considered as an important aspect behind the resistance or
susceptibility of the host to an infectious disease. Over the years, researchers have explored …

Natural selection and infectious disease in human populations

EK Karlsson, DP Kwiatkowski, PC Sabeti - Nature Reviews Genetics, 2014 - nature.com
The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

Lyme arthritis: linking infection, inflammation and autoimmunity

RB Lochhead, K Strle, SL Arvikar, JJ Weis… - Nature Reviews …, 2021 - nature.com
Infectious agents can trigger autoimmune responses in a number of chronic inflammatory
diseases. Lyme arthritis, which is caused by the tick-transmitted spirochaete Borrelia …

Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells

S Tartey, O Takeuchi - International reviews of immunology, 2017 - Taylor & Francis
The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which
include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin …

The anti-inflammatory effect of taurine on cardiovascular disease

T Qaradakhi, LK Gadanec, KR McSweeney… - Nutrients, 2020 - mdpi.com
Taurine is a non-protein amino acid that is expressed in the majority of animal tissues. With
its unique sulfonic acid makeup, taurine influences cellular functions, including …

Innate Immune Recognition of Mycobacterium tuberculosis

J Kleinnijenhuis, M Oosting… - Journal of …, 2011 - Wiley Online Library
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a major health problem,
with 10 million new cases diagnosed each year. Innate immunity plays an important role in …