Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems
MP Mattson, R Wan - The Journal of nutritional biochemistry, 2005 - Elsevier
Intermittent fasting (IF; reduced meal frequency) and caloric restriction (CR) extend lifespan
and increase resistance to age-related diseases in rodents and monkeys and improve the …
and increase resistance to age-related diseases in rodents and monkeys and improve the …
VMAT2‐Deficient Mice Display Nigral and Extranigral Pathology and Motor and Nonmotor Symptoms of Parkinson′ s Disease
Dopamine is transported into synaptic vesicles by the vesicular monoamine transporter
(VMAT2; SLC18A2). Disruption of dopamine storage has been hypothesized to damage the …
(VMAT2; SLC18A2). Disruption of dopamine storage has been hypothesized to damage the …
Scalable generalized linear mixed model for region-based association tests in large biobanks and cohorts
With very large sample sizes, biobanks provide an exciting opportunity to identify genetic
components of complex traits. To analyze rare variants, region-based multiple-variant …
components of complex traits. To analyze rare variants, region-based multiple-variant …
Circadian variation of blood pressure and the vascular response to asynchronous stress
AM Curtis, Y Cheng, S Kapoor… - Proceedings of the …, 2007 - National Acad Sciences
The diurnal variation in the incidence of myocardial infarction and stroke may reflect an
influence of the molecular clock and/or the time dependence of exposure to environmental …
influence of the molecular clock and/or the time dependence of exposure to environmental …
Vascular PPARγ controls circadian variation in blood pressure and heart rate through Bmal1
N Wang, G Yang, Z Jia, H Zhang, T Aoyagi, S Soodvilai… - Cell metabolism, 2008 - cell.com
Thiazolidinediones (TZDs) are PPARγ activators that exhibit vasculoprotective properties. To
determine the vascular function of PPARγ, we analyzed Tie2Cre/flox and SM22Cre/flox …
determine the vascular function of PPARγ, we analyzed Tie2Cre/flox and SM22Cre/flox …
Norepinephrine loss produces more profound motor deficits than MPTP treatment in mice
KS Rommelfanger, GL Edwards… - Proceedings of the …, 2007 - National Acad Sciences
Although Parkinson's disease (PD) is characterized primarily by loss of nigrostriatal
dopaminergic neurons, there is a concomitant loss of norepinephrine (NE) neurons in the …
dopaminergic neurons, there is a concomitant loss of norepinephrine (NE) neurons in the …
Dbh+ catecholaminergic cardiomyocytes contribute to the structure and function of the cardiac conduction system in murine heart
T Sun, A Grassam-Rowe, Z Pu, Y Li, H Ren… - Nature …, 2023 - nature.com
The heterogeneity of functional cardiomyocytes arises during heart development, which is
essential to the complex and highly coordinated cardiac physiological function. Yet the …
essential to the complex and highly coordinated cardiac physiological function. Yet the …
Vagal tone dominates autonomic control of mouse heart rate at thermoneutrality
It is generally accepted that cardiac sympathetic tone dominates the control of heart rate
(HR) in mice. However, we have recently challenged this notion given that HR in the mouse …
(HR) in mice. However, we have recently challenged this notion given that HR in the mouse …
Catecholamine neurones in rats modulate sleep, breathing, central chemoreception and breathing variability
A Li, E Nattie - The Journal of physiology, 2006 - Wiley Online Library
Brainstem catecholamine (CA) neurones have wide projections and an arousal‐state‐
dependent activity pattern. They are thought to modulate the processing of sensory …
dependent activity pattern. They are thought to modulate the processing of sensory …
Catecholamines augment collateral vessel growth and angiogenesis in hindlimb ischemia
D Chalothorn, H Zhang, JA Clayton… - American Journal …, 2005 - journals.physiology.org
Catecholamine stimulation of α1-adrenoceptors exerts growth factor-like activity, mediated
by generation of reactive oxygen species, on arterial smooth muscle cells and adventitial …
by generation of reactive oxygen species, on arterial smooth muscle cells and adventitial …