The interindividual genetic variations in drug metabolizing enzymes and transporters
influence the efficacy and toxicity of numerous drugs. As a fundamental element in precision …

The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug
response and adverse reactions to a great extent. This variation includes copy number …

This article explores contemporary biopolitics in the light of Michel Foucault's oft quoted
suggestion that contemporary politics callslife itself'into question. It suggests that recent …

Background In the PLATO trial of ticagrelor versus clopidogrel for treatment of acute
coronary syndromes, ticagrelor reduced the composite outcome of cardiovascular death …

Differences in drug responsiveness are common, often leading to challenges in optimizing
the dosage regimen for a particular patient. Recent advances provide a rational framework …

Considered a classic in the field, Troy Duster's Backdoor to Eugenics was a groundbreaking
book that grappled with the social and political implications of the new genetic technologies …

Importance The antiepileptic drug phenytoin can cause cutaneous adverse reactions,
ranging from maculopapular exanthema to severe cutaneous adverse reactions, which …

Abstract Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …

Background The ability of adult humans to digest the milk sugar lactose-lactase persistence-
is a dominant Mendelian trait that has been a subject of extensive genetic, medical and …

Introduction: Variability of drug response is an important consideration in clinical medicine. A
major determinant of drug response variability is hepatic cytochrome P450 oxidase …