The major human liver drug metabolising cytochrome P450 (CYP) enzymes are
downregulated during inflammation and infectious disease state, especially during …

Since the reports of the first cases of COVID-19, in less than 5 years, a huge number of
documents regarding that disease and the coronavirus (SARS-CoV-2), responsible for the …

Nirmatrelvir and GC373 inhibit the SARS-CoV-2 3CL protease and hinder viral replication in
COVID-19. As nirmatrelvir in Paxlovid is oxidized by cytochrome P450 3A4, ritonavir is …

Calcitonin (CT) and adrenomedullin (ADM) are members of the CT family. Procalcitonin
(PCT) is a prohormone of CT. Elevations in serum PCT and ADM levels are associated with …

Background: Molnupiravir is a ribonucleoside analog and exhibits its antiviral mechanism by
inhibiting replication. Preclinical studies have been reported that support the role of …

Text-Book of Medicine by American Authors, a foundational reading for medical students
and practitioners worldwide. The treatment started with 6 drops of belladonna mixture, which …

At the end of 2019, a new disease was reported in Wuhan China and described such as
severe acute respiratory syndrome (SARS). This new virus named SARSCoV-2 S is …

Onemocnění COVID-19 stále představuje pro rizikové osoby život ohrožující stav s velmi
heterogenním klinickým obrazem. V současné době je snaha najít vhodný laboratorní …

Two key enzyme families, cytochrome P450s (CYPs) and their redox partner, cytochrome
P450 reductase (CPR), work together to provide essential functions for human health. They …