Development and structural modifications of cholinesterase reactivators against chemical warfare agents in last decade: a review

R Sharma, B Gupta, N Singh… - Mini Reviews in …, 2015 - ingentaconnect.com
Organophosphate (OP) pesticides and nerve agents are responsible for suicidal and
accidental poisonings. The acute toxicity of nerve agents leads to progressive inhibition of …

Oxime functionality in surfactant self-assembly: an overview on combating toxicity of organophosphates

N Singh, Y Karpichev, AK Tiwari, K Kuca… - Journal of Molecular …, 2015 - Elsevier
There is an immediate need to develop new strategies for detoxification and
decontamination of organophosphorus-containing nerve agents and pesticides. Oximes …

Gold nanoprobe for inhibition and reactivation of acetylcholinesterase: an application to detection of organophosphorus pesticides

ML Satnami, J Korram, R Nagwanshi… - Sensors and Actuators B …, 2018 - Elsevier
The organophosphorus compound (OP) induced inhibition of acetylcholinesterase (AChE)
and their reactivation has been monitored using gold nanoprobe. The method is based on …

Development and validation of a FIA/UV–vis method for pKa determination of oxime based acetylcholinesterase reactivators

K Musil, V Florianova, P Bucek, V Dohnal… - … of Pharmaceutical and …, 2016 - Elsevier
Acetylcholinesterase reactivators (oximes) are compounds used for antidotal treatment in
case of organophosphorus poisoning. The dissociation constants (pK a1) of ten standard or …

The experimental oxime K027—a promising protector from organophosphate pesticide poisoning. A review comparing K027, K048, pralidoxime, and obidoxime

DE Lorke, GA Petroianu - Frontiers in neuroscience, 2019 - frontiersin.org
Poisoning with organophosphorus compounds (OPCs) is a major problem worldwide.
Standard therapy with atropine and established oxime-type enzyme reactivators …

An example of green surfactant systems based on inherently biodegradable IL-derived amphiphilic oximes

SJ Pandya, IV Kapitanov, Z Usmani, R Sahu… - Journal of Molecular …, 2020 - Elsevier
Progress in the development of biodegradable ionic liquids (ILs) leads to designing green
surfactant formulations for miscellaneous applications. In this work, we present synthesis of …

Facile and visual detection of acetylcholinesterase inhibitors by carbon quantum dots

B Gupta, R Sharma, KK Ghosh - New Journal of Chemistry, 2019 - pubs.rsc.org
Sensitive and rapid detection of organophosphate toxicants is highly relevant and important
in environmental protection and food safety. Owing to this, a carbon quantum dot (CQD) …

Preferential Door for Ligand Binding and Unbinding Pathways in Inhibited Human Acetylcholinesterase

N Kongkaew, K Hengphasatporn… - The Journal of …, 2024 - ACS Publications
Rising global population and increased food demands have resulted in the increased use of
organophosphate pesticides (OPs), leading to toxin accumulation and transmission to …

Synthesis and in-vitro reactivation screening of imidazolium aldoximes as reactivators of sarin and VX-inhibited human acetylcholinesterase (hAChE)

R Sharma, B Gupta, AK Sahu, J Acharya… - Chemico-biological …, 2016 - Elsevier
Post-treatment of organophosphate (OP) poisoning involves the application of oxime
reactivator as an antidote. Structurally different oximes are widely studied to examine their …

Glycosylated-imidazole aldoximes as reactivators of pesticides inhibited AChE: Synthesis and in-vitro reactivation study

R Sharma, K Upadhyaya, B Gupta, KK Ghosh… - Environmental …, 2020 - Elsevier
The present armamentarium of commercially available antidotes provides limited protection
against the neurological effects of organophosphate exposure. Hence, there is an urgent …