Glycoproteins play crucial roles in various biological processes. To investigate the
relationship between glycan structure and function, researchers have employed various …

Heparin and heparan sulfate represent key members of the glycosaminoglycan family of
carbohydrates and underpin considerable repertoires of biological importance. As such …

Proteoglycans (PGs), consisting of glycosaminoglycans (GAGs) linked with the core protein
through a tetrasaccharide linkage region, play roles in many important biological events …

Comprehensive Summary Protein glycosylation is the most complex and diverse form of
post‐translational modification in human body. Meanwhile, glycosylation of peptides and …

Per-and polyfluoroalkyl substances (PFASs) are a class of environmentally persistent
industrial compounds that disrupt various metabolic pathways. Among the protein receptors …

Proteoglycans are heterogeneous macromolecular glycoconjugates that orchestrate many
important cellular processes. While much attention has focused on the poly-sulfated …

Abstract Pixatimod (PG545), a heparan sulfate (HS) mimetic and anticancer agent currently
in clinical trials, is a potent inhibitor of heparanase. Heparanase is an endo‐β …

Sulfation widely exists in the eukaryotic proteome. However, understanding the biological
functions of sulfation in peptides and proteins has been hampered by the lack of methods to …

Compounds that mimic the biological properties of glycosaminoglycans (GAGs) and can be
more easily prepared than the native GAG oligosaccharides are highly demanded. Here, we …

A new convergent chemoenzymatic synthesis strategy, integrating enzymatic synthesis of
heparan sulfate, sortase A ligation, copper (I)-catalyzed alkyne–azide cycloaddition, and …