[HTML][HTML] Biomarker Landscape in RASopathies

N Ferrito, J Báez-Flores, M Rodríguez-Martín… - International Journal of …, 2024 - mdpi.com
RASopathies are a group of related genetic disorders caused by mutations in genes within
the RAS/MAPK signaling pathway. This pathway is crucial for cell division, growth, and …

Cell type mapping of inflammatory muscle diseases highlights selective myofiber vulnerability in inclusion body myositis

S Wischnewski, T Thäwel, C Ikenaga, A Kocharyan… - Nature Aging, 2024 - nature.com
Inclusion body myositis (IBM) is the most prevalent inflammatory muscle disease in older
adults with no effective therapy available. In contrast to other inflammatory myopathies such …

Schwann cell derived pleiotrophin stimulates fibroblast for proliferation and excessive collagen deposition in plexiform neurofibroma

Z Tian, Z Du, G Bai, Q Gong, Y You, G Xu, J Liu… - Cancer Gene …, 2024 - nature.com
Neurofibromatosis type 1 associated plexiform neurofibroma (pNF) is characterized by
abundant fibroblasts and dense collagen, yet the intricate interactions between tumor-origin …

[HTML][HTML] Targeting the extracellular matrix for NF1-associated neurofibroma treatment

C Jiang - Chinese Journal of Plastic and Reconstructive Surgery, 2024 - Elsevier
Abstract Neurofibromatosis type 1 (NF1) is one of the most common genetic disorders that
predisposes patients to benign and malignant tumors of the peripheral nervous system …