Role of interleukin-6 in cancer progression and therapeutic resistance

N Kumari, BS Dwarakanath, A Das, AN Bhatt - Tumor Biology, 2016 - Springer
In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

Targeting interleukin-6 in inflammatory autoimmune diseases and cancers

X Yao, J Huang, H Zhong, N Shen, R Faggioni… - Pharmacology & …, 2014 - Elsevier
Abstract Interleukin-6 (IL-6) is a pleiotropic cytokine with significant functions in the
regulation of the immune system. As a potent pro-inflammatory cytokine, IL-6 plays a pivotal …

Interleukin-6 signaling pathway in targeted therapy for cancer

Y Guo, F Xu, TJ Lu, Z Duan, Z Zhang - Cancer treatment reviews, 2012 - Elsevier
Interleukin-6 (IL-6) is a multifunctional cytokine which plays an important role in a wide
range of biologic activities in different types of cell including tumor cells. IL-6 is involved in …

Chronic inflammation in cancer development

G Multhoff, M Molls, J Radons - Frontiers in immunology, 2012 - frontiersin.org
Chronic inflammatory mediators exert pleiotropic effects in the development of cancer. On
the one hand, inflammation favors carcinogenesis, malignant transformation, tumor growth …

[HTML][HTML] A cytokine-mediated link between innate immunity, inflammation, and cancer

WW Lin, M Karin - The Journal of clinical investigation, 2007 - Am Soc Clin Investig
It has been established that cancer can be promoted and/or exacerbated by inflammation
and infections. Indeed, chronic inflammation orchestrates a tumor-supporting …

Inflammation: gearing the journey to cancer

JK Kundu, YJ Surh - Mutation Research/Reviews in Mutation Research, 2008 - Elsevier
Chronic inflammation plays a multifaceted role in carcinogenesis. Mounting evidence from
preclinical and clinical studies suggests that persistent inflammation functions as a driving …

Physical activity and modulation of systemic low-level inflammation

H Bruunsgaard - Journal of leukocyte biology, 2005 - academic.oup.com
It has been recognized for some time that cardiovascular disease and type 2 diabetes are, to
a major extent, inflammatory disorders associated with an environment characterized by a …

Interleukin‐6 and its receptor in cancer: implications for translational therapeutics

DS Hong, LS Angelo, R Kurzrock - Cancer, 2007 - Wiley Online Library
Abstract Interleukin‐6 (IL‐6) plays a major role in the response to injury or infection and is
involved in the immune response, inflammation, and hematopoiesis. Its deregulation …

[图书][B] Statistical methods in genetic epidemiology

DC Thomas - 2004 - books.google.com
This well-organized and clearly written text has a unique focus on methods of identifying the
joint effects of genes and environment on disease patterns. It follows the natural sequence of …

Gene of the month: Interleukin 6 (IL-6)

P Ataie-Kachoie, MH Pourgholami… - Journal of clinical …, 2014 - jcp.bmj.com
The Interleukin 6 (IL-6) gene encodes the classic proinflammatory cytokine IL-6. It is also
known as interferon-β2 (IFN-β2), B cell stimulatory factor-2 and hybridoma/plasmacytoma …