Programmed and self-organized flow of information during morphogenesis
C Collinet, T Lecuit - Nature Reviews Molecular Cell Biology, 2021 - nature.com
How the shape of embryos and organs emerges during development is a fundamental
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …
question that has fascinated scientists for centuries. Tissue dynamics arise from a small set …
Integration of actin dynamics and cell adhesion by a three-dimensional, mechanosensitive molecular clutch
LB Case, CM Waterman - Nature cell biology, 2015 - nature.com
During cell migration, the forces generated in the actin cytoskeleton are transmitted across
transmembrane receptors to the extracellular matrix or other cells through a series of …
transmembrane receptors to the extracellular matrix or other cells through a series of …
From morphogen to morphogenesis and back
D Gilmour, M Rembold, M Leptin - Nature, 2017 - nature.com
A long-term aim of the life sciences is to understand how organismal shape is encoded by
the genome. An important challenge is to identify mechanistic links between the genes that …
the genome. An important challenge is to identify mechanistic links between the genes that …
A self-organized biomechanical network drives shape changes during tissue morphogenesis
Tissue morphogenesis is orchestrated by cell shape changes. Forces required to power
these changes are generated by non-muscle myosin II (MyoII) motor proteins pulling …
these changes are generated by non-muscle myosin II (MyoII) motor proteins pulling …
Generation of stress fibers through myosin-driven reorganization of the actin cortex
JI Lehtimäki, EK Rajakylä, S Tojkander, P Lappalainen - Elife, 2021 - elifesciences.org
Contractile actomyosin bundles, stress fibers, govern key cellular processes including
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …
A mechanosensitive RhoA pathway that protects epithelia against acute tensile stress
Adherens junctions are tensile structures that couple epithelial cells together. Junctional
tension can arise from cell-intrinsic application of contractility or from the cell-extrinsic forces …
tension can arise from cell-intrinsic application of contractility or from the cell-extrinsic forces …
Myosin II controls junction fluctuations to guide epithelial tissue ordering
Under conditions of homeostasis, dynamic changes in the length of individual adherens
junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the …
junctions (AJs) provide epithelia with the fluidity required to maintain tissue integrity in the …
Actomyosin meshwork mechanosensing enables tissue shape to orient cell force
Sculpting organism shape requires that cells produce forces with proper directionality. Thus,
it is critical to understand how cells orient the cytoskeleton to produce forces that deform …
it is critical to understand how cells orient the cytoskeleton to produce forces that deform …
RhoA GTPase inhibition organizes contraction during epithelial morphogenesis
FM Mason, S Xie, CG Vasquez, M Tworoger… - Journal of Cell …, 2016 - rupress.org
During morphogenesis, contraction of the actomyosin cytoskeleton within individual cells
drives cell shape changes that fold tissues. Coordination of cytoskeletal contractility is …
drives cell shape changes that fold tissues. Coordination of cytoskeletal contractility is …
Excitable RhoA dynamics drive pulsed contractions in the early C. elegans embryo
JB Michaux, FB Robin, WM McFadden… - Journal of Cell …, 2018 - rupress.org
Pulsed actomyosin contractility underlies diverse modes of tissue morphogenesis, but the
underlying mechanisms remain poorly understood. Here, we combined quantitative imaging …
underlying mechanisms remain poorly understood. Here, we combined quantitative imaging …