IL-6 in inflammation, autoimmunity and cancer

T Hirano - International immunology, 2021 - academic.oup.com
IL-6 is involved both in immune responses and in inflammation, hematopoiesis, bone
metabolism and embryonic development. IL-6 plays roles in chronic inflammation (closely …

[HTML][HTML] JAK-STAT signaling: a double-edged sword of immune regulation and cancer progression

KL Owen, NK Brockwell, BS Parker - Cancers, 2019 - mdpi.com
Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling mediates
almost all immune regulatory processes, including those that are involved in tumor cell …

Interleukin-6: a masterplayer in the cytokine network

P Uciechowski, W Dempke - Oncology, 2020 - karger.com
Abstract Interleukin-6 (IL-6) is a member of the pro-inflammatory cytokine family, induces the
expression of a variety of proteins responsible for acute inflammation, and plays an …

A panoramic review of IL-6: Structure, pathophysiological roles and inhibitors

S Kaur, Y Bansal, R Kumar, G Bansal - Bioorganic & medicinal chemistry, 2020 - Elsevier
Abstract Interleukin-6 (IL-6) is a pleiotropic pro-inflammatory cytokine. Its deregulation is
associated with chronic inflammation, and multifactorial auto-immune disorders. It mediates …

[HTML][HTML] C-reactive protein and cancer—diagnostic and therapeutic insights

PC Hart, IM Rajab, M Alebraheem… - Frontiers in …, 2020 - frontiersin.org
Cancer disease describes any pathology involving uncontrolled cell growth. As cells
duplicate, they can remain localized in defined tissues, forming tumor masses and altering …

[HTML][HTML] IL-6: the link between inflammation, immunity and breast cancer

J Chen, Y Wei, W Yang, Q Huang, Y Chen… - Frontiers in …, 2022 - frontiersin.org
Breast cancer is one of the leading causes of mortality in females. Over the past decades,
intensive efforts have been made to uncover the pathogenesis of breast cancer. Interleukin …

[HTML][HTML] Potentials for health and therapeutic benefits of garlic essential oils: Recent findings and future prospects

TPC Ezeorba, KI Chukwudozie, CA Ezema… - Pharmacological …, 2022 - Elsevier
Garlic (Allium sativum) has been known for its potent medicinal activities and its interesting
culinary role since ancient times. With over 200 phytochemicals and flavoring compounds …

[HTML][HTML] Chronic inflammation: key player and biomarker-set to predict and prevent cancer development and progression based on individualized patient profiles

S Qian, O Golubnitschaja, X Zhan - Epma Journal, 2019 - Springer
A strong relationship exists between tumor and inflammation, which is the hot point in cancer
research. Inflammation can promote the occurrence and development of cancer by …

Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression

Q Huang, M Wu, X Wu, Y Zhang, Y Xia - Biochimica et Biophysica Acta …, 2022 - Elsevier
Physical exercise has gradually become a focus in cancer treatment due to its pronounced
role in reducing cancer risk, enhancing therapeutic efficacy, and improving prognosis. In …

The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics

M Abbasifard, H Khorramdelazad - Life sciences, 2020 - Elsevier
Abstract Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many
innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel …