CNS disorders are on the rise despite advancements in our understanding of their
pathophysiological mechanisms. A major hurdle to the treatment of these disorders is the …

The blood–brain barrier (BBB) is formed by brain microvascular endothelial cells that are
sealed by tight junctions, making it a significant obstacle for most brain therapeutics. The …

Ischemic stroke is a vascular central nervous system (CNS) disease that leads a disability
and death. Thrombolysis and neuroprotection are the primary treatment strategies of …

Cancer nanomedicine vehicles are required to cross the vascular barrier to reach the tumor
site in order to ensure the successful delivery of their therapeutic load. Here, nanodiamond …

From the global perspective, stroke refers to a highly common cause of disability and death.
Ischemic stroke (IS), attributed to blood vessel blockage, preventing the flow of blood to …

The blood–brain barrier (BBB) is partially disrupted in brain tumors. Despite the gaps in the
BBB, there is an inadequate amount of pharmacological agents delivered into the brain …

As a highly selective and semi-permeable barrier that separates the circulating blood from
the brain and central nervous system (CNS), the blood-brain barrier (BBB) plays a critical …

Owing to its intricate pathophysiology, cerebral stroke is a serious medical condition caused
by interruption or obstruction of blood supply (blockage of vasculature) to the brain tissues …

The blood–brain barrier (BBB) selectively controls the passage of endogenous and
exogenous molecules between systemic circulation and the brain parenchyma. Nanocarrier …

Thrombolysis has been a standard treatment for ischemic stroke. However, only 2-7%
patients benefit from it because the thrombolytic agent has to be injected within 4.5 h after …