Gene therapy is one of the most advanced therapies in current medicine. In particular,
interference RNA-based therapy by small interfering RNA (siRNA) has gained attention in …

Bone sarcomas are malignant tumors of mesenchymal origin. Complete surgical resection is
the cornerstone of multidisciplinary treatment. However, advanced, unresectable forms …

Nucleic acid-based therapies have become the third major drug class after small molecules
and antibodies. The role of nucleic acid-based therapies has been strengthened by recent …

Anti-vascular endothelial growth factor (VEGF) therapies have revolutionized the treatment
of neovascular age-related macular degeneration (nAMD) and other retinal diseases …

Oligonucleotides are a rapidly emerging class of therapeutics. Their most well-known
examples are informational drugs that modify gene expression by binding mRNA. Despite …

The simultaneous delivery of CpG oligonucleotide along with short interfering RNA (siRNA)
has the potential to significantly boost the anticancer impact of siRNA medications. Our …

Abstract Background Small interfering RNA (siRNA) holds great promise for treating various
lung diseases, but the lack of safe and efficient pulmonary siRNA delivery systems has …

Small interfering RNA (siRNA) holds significant therapeutic potential by silencing target
genes through RNA interference. Current clinical applications of siRNA have been primarily …

Purpose: This research investigated the development of short hairpin RNA (shRNA)
molecules designed to target specific regions of the human respiratory syncytial virus …

Ocular diseases pose a significant challenge due to the unique structure and function of the
eye. Traditional drug delivery methods often struggle to achieve high efficacy while …