Recent advance in oxazole-based medicinal chemistry
HZ Zhang, ZL Zhao, CH Zhou - European journal of medicinal chemistry, 2018 - Elsevier
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
ring are readily able to bind with a variety of enzymes and receptors in biological systems …
[HTML][HTML] 1, 3, 4-Oxadiazole-containing hybrids as potential anticancer agents: Recent developments, mechanism of action and structure-activity relationships
S Nayak, SL Gaonkar, EA Musad… - Journal of Saudi Chemical …, 2021 - Elsevier
Chemotherapy is an important therapeutic approach for the treatment of cancer. Currently,
many anticancer drugs are available in the market that plays an important role in cancer …
many anticancer drugs are available in the market that plays an important role in cancer …
[HTML][HTML] Berberine prevents non-alcoholic steatohepatitis-derived hepatocellular carcinoma by inhibiting inflammation and angiogenesis in mice
Y Luo, G Tian, Z Zhuang, J Chen, N You… - American journal of …, 2019 - ncbi.nlm.nih.gov
Hepatocellular carcinoma (HCC) is one of the most malignant and poor prognosis tumors,
which was increasingly caused by nonalcoholic fatty liver disease/nonalcoholic …
which was increasingly caused by nonalcoholic fatty liver disease/nonalcoholic …
Design, synthesis and molecular docking of benzophenone conjugated with oxadiazole sulphur bridge pyrazole pharmacophores as anti inflammatory and analgesic …
AR Gulnaz, YHE Mohammed, SA Khanum - Bioorganic Chemistry, 2019 - Elsevier
The prostaglandins (PG) a group of physiologically active lipid compounds having diverse
hormone like effects are important mediators of the body's response to pain and …
hormone like effects are important mediators of the body's response to pain and …
Synthesis, characterization, hirshfeld surface analysis, crystal structure and molecular modeling studies of 1-(4-(Methoxy (phenyl) methyl)-2-methylphenoxy) butan-2 …
The crystal compound was synthesized and characterized using conventional analytical
techniques. The compound C19H21O3 crystallizes in a monoclinic crystal system with the …
techniques. The compound C19H21O3 crystallizes in a monoclinic crystal system with the …
[HTML][HTML] Kaempferol relieves the DSS-induced chronic colitis in C57BL/6J mice, alleviates intestinal angiogenesis, and regulates colonic microflora structure
R Yu, Q Zhou, T Liu, P Liu, H Li, Y Bian, Z Liu - Journal of Functional Foods, 2023 - Elsevier
Purpose The progression of chronic colitis is accompanied by an increase in inflammation
and intestinal angiogenesis. Kaempferol, a dietary flavonoid, has been shown to exhibit anti …
and intestinal angiogenesis. Kaempferol, a dietary flavonoid, has been shown to exhibit anti …
BP-1T, an antiangiogenic benzophenone-thiazole pharmacophore, counteracts HIF-1 signalling through p53/MDM2-mediated HIF-1α proteasomal degradation
Hypoxia is a feature of all solid tumours, contributing to tumour progression. Activation of HIF-
1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its …
1α plays a critical role in promoting tumour angiogenesis and metastasis. Since its …
A tumoural angiogenic gateway blocker, Benzophenone-1B represses the HIF-1α nuclear translocation and its target gene activation against neoplastic progression
Hypoxia is an important module in all solid tumours to promote angiogenesis, invasion and
metastasis. Stabilization and subsequent nuclear localization of HIF-1α subunits result in the …
metastasis. Stabilization and subsequent nuclear localization of HIF-1α subunits result in the …
Synthesis and in vitro activity of novel melphalan analogs in hematological Malignancy cells
A Poczta, P Krzeczyński, J Tobiasz, A Rogalska… - International Journal of …, 2022 - mdpi.com
Despite the continuous developments in pharmacology and the high therapeutic effect of
new treatment options for patients with hematological malignancies, these diseases remain …
new treatment options for patients with hematological malignancies, these diseases remain …
Synthesis and antiproliferative activity of benzophenone tagged pyridine analogues towards activation of caspase activated DNase mediated nuclear fragmentation in …
M Al-Ghorbani, P Thirusangu, HD Gurupadaswamy… - Bioorganic …, 2016 - Elsevier
A series of benzophenones possessing pyridine nucleus 8a–l were synthesized by multistep
reaction sequence and evaluated for antiproliferative activity against DLA cells by in vitro …
reaction sequence and evaluated for antiproliferative activity against DLA cells by in vitro …