Since optical coherence tomography (OCT) was first performed in humans two decades ago,
this imaging modality has been widely adopted in research on coronary atherosclerosis and …

Atherosclerotic Plaque Healing Atherosclerotic plaque rupture and erosion result in acute
coronary syndromes. Plaque healing after initial disruption has been less extensively …

Well into the 21st century, we still triage acute myocardial infarction on the basis of the
presence or absence of ST-segment elevation, a century-old technology. Meanwhile, we …

Atherosclerosis is a silent chronic vascular pathology that is the cause of the majority of
cardiovascular ischaemic events. The evolution of vascular disease involves a combination …

The notion that heart attacks develop from coronary-artery stenosis is an oversimplification
of a process involving lipid metabolism, inflammation, macrophage activation, collagen …

The concept of the so-called 'vulnerable plaque'has proved highly useful to guide research
and thinking regarding the pathophysiology of the acute coronary syndromes (ACS). Yet, the …

This Review provides an epidemiological overview of global mortality from acute coronary
syndromes (ACS). Across the regions of the world where data are available, mortality from …

Since an association between myocardial infarction (MI) and respiratory infections has been
described for influenza viruses and other respiratory viral agents, understanding possible …

Inflammation has been long regarded as a key contributor to atherosclerosis. Inflammatory
cells and soluble mediators play critical roles throughout arterial plaque development and …

Aims Patients presenting with acute coronary syndrome (ACS) may have different plaque
morphologies at the culprit lesion. In particular, plaque rupture (PR) has been shown as the …