The zebrafish pancreas shares its basic organization and cell types with the mammalian
pancreas. In addition, the developmental pathways that lead to the establishment of the …

Paired box 4 (Pax4) is a key transcription factor involved in the embryonic development of
the pancreatic islets of Langerhans. Consisting of a conserved paired box domain and a …

The coding variant (p. Arg192His) in the transcription factor PAX4 is associated with an
altered risk for type 2 diabetes (T2D) in East Asian populations. In mice, Pax4 is essential for …

The interconversion of cell lineages via transdifferentiation is an adaptive mode of tissue
regeneration and an appealing therapeutic target. However, its clinical exploitation is …

Alzheimer's Disease (AD) and Type 2 Diabetes (T2D) share a common hallmark of insulin
resistance. Reportedly, two non-canonical Receptor Tyrosine Kinases (RTKs), ALK and …

There is great interest in therapeutically harnessing endogenous regenerative mechanisms
to increase the number of β cells in people with diabetes. By performing whole‐genome …

Background Endocrine cells of the zebrafish digestive system play an important role in
regulating metabolism and include pancreatic endocrine cells (PECs) clustered in the islets …

Pancreatic ε-cells producing ghrelin are one type of endocrine cell found in islets, which
have been shown to influence other intra-islet cells, especially in regulating the function of β …

Thyroid hormone (TH) signaling promotes tissue maturation and adult organ formation.
Developmental transitions alter an organism's metabolic requirements, and it remains …

Although zebrafish is used to model human diseases through mutational and morpholino-
based knockdown approaches, there are currently no robust transgenic knockdown tools …