Clozapine (CLZ) is the drug of choice for the treatment of resistant schizophrenia; however,
its suitable use is limited by the complex adverse effects' profile. The best-described adverse …

Clozapine is exceptionally effective in psychotic disorders and can reduce suicidal risk.
Nevertheless, its use is limited due to potentially life-threatening adverse effects, including …

Carpenter and Buchanan1 concluded that “the paradigm should be 2 steps, not 3—that is,
failure to respond to 2 antipsychotic drugs, then taking clozapine, rather than failure to …

Clozapine, an atypical antipsychotic, is a dibenzodiazepine derivative and its therapeutic
effects are probably mediated by dopaminergic and serotonergic activity. In accordance to …

Clozapine is the first second generation antipsychotic with different receptor profile of action.
Clozapine is the most efficacious drug for the treatment of psychotic disorder and is the drug …

The start of the era of modern psychopharmacology can be dated from 1949, with the
introduction of lithium carbonate in Melbourne, Australia, as a selective and effective …

Schizophrenia is a functional psychosis with a multifactorial etiopathogeny involving genetic,
endocrine and immunological risk factors. The main pathogenic hypothesis involves …

Severe neutropenia, defined as absolute neutrophil count (ANC)< 500/µL, is a well-known
adverse effect of clozapine that requires specific clinical monitoring, a requirement that was …

Introduction. The state of health of patients with schizophrenia is a field of growing interest
that has probably not received sufficient attention in the past. It is currently held that physical …

Conclusiones. Describimos una alta frecuencia de ECV tanto en el global de nuestra serie
de pacientes con enfermedad mental severa a los que se realizó una interconsulta a …