Objective A systematic review and a meta-analysis were carried out in order to summarize
the current published studies and to evaluate LINE-1 hypomethylation in blood and other …

Most human phenotypes are influenced by a combination of genomic and environmental
factors. Engaging in regular physical exercise prevents many chronic diseases, decreases …

Tissue-specific DNA methylation is found at promoters, enhancers, and CpG islands but also
over larger genomic regions. In most human tissues, the vast majority of the genome is …

Although 30% of individuals diagnosed with colorectal cancer (CRC) report a family history
of the disease, only 5% to 6% carry germline mutations in genes associated with known …

Lung cancer is recognized as a leading cause of cancer-related death worldwide and its
frequency is still increasing. The prognosis in lung cancer is poor and limited by the …

Introduction Up to one third of colorectal cancers show familial clustering and 5% are
hereditary single-gene disorders. Hereditary non-polyposis colorectal cancer comprises …

Little is known about epigenetics and its possible role in atherosclerosis. We here analysed
histone and DNA methylation and the expression of corresponding methyltransferases in …

Chlorpyrifos (CPF) is an organophosphorus pesticide used for agricultural pest control all
over the world. We have previously demonstrated that environmental concentrations of this …

LINE‐1 (L1) is the most abundant mammalian transposable element that comprises nearly
20% of the genome, and nearly half of the mammalian genome has stemmed from L1 …

Extracellular vesicles (EVs) are central to intercellular communication and play an important
role in cancer progression and development. Osteosarcoma (OS) is an aggressive bone …