With increasing life expectations, more and more patients suffer from fractures either
induced by intensive sports or other bone-related diseases. The balance between …

The tooth provides an excellent system for deciphering the molecular mechanisms of
organogenesis, and has thus been of longstanding interest to developmental and stem cell …

The genetic elements required to tune gene expression are partitioned in active and
repressive nuclear condensates. Chromatin compartments include transcriptional clusters …

Osteoporosis is metabolic bone disease caused by an altered balance between bone
anabolism and catabolism. This dysregulated balance is responsible for fragile bones that …

The identification of disease-causing mutations has in recent years progressed immensely
due to whole genome sequencing approaches using patient material. The task accordingly …

Segmentation of the axial skeleton in amniotes depends on the segmentation clock, which
patterns the paraxial mesoderm and the sclerotome. While the segmentation clock clearly …

Alternative splicing generates distinct mRNA variants and is essential for development,
homeostasis, and renewal. Proteins of the serine/arginine (SR)-rich splicing factor family are …

Osterix (or Sp7) is an important transcription factor that promotes osteoblast differentiation by
modulating the expression of a range of target genes. Although many studies have focused …

Zebrafish mutants with increased retinoic acid (RA) signaling due to the loss of the RA-
inactivating enzyme Cyp26b1 develop a hyper-mineralized spine with gradually fusing …

Oryzias latipes is increasingly used as a model in biomedical skeletal research. The
standard approach is to generate genetic variants with particular skeletal phenotypes which …