The possible link between hIAPP accumulation and β-cell death in diabetic patients has
inspired numerous studies focusing on amyloid structures and aggregation pathways of this …

Deamidation is a nonenzymatic and spontaneous posttranslational modification (PTM) that
introduces changes in both structure and charge of proteins, strongly associated with aging …

Type 2 Diabetes is a major public health threat, and its prevalence is increasing worldwide.
The abnormal accumulation of islet amyloid polypeptide (IAPP) in pancreatic β-cells is …

Spontaneous chemical modifications play an important role in human disease and aging at
the molecular level. Deamidation and isomerization are known to be among the most …

Amyloid fibril formation is a hallmark in a range of human diseases. Analysis of the
molecular details of amyloid aggregation, however, is limited by the difficulties in …

Spontaneous deamidation of amino acids is a physiologically important process, particularly
for protein aging and diseases. Despite its widespread occurrence, the mechanism of …

Two-dimensional mass spectrometry (2D MS) is a tandem mass spectrometry method that
relies on manipulating ion motions to correlate precursor and fragment ion signals. 2D mass …

Deamidated amyloid proteins have been shown to accelerate fibril formation. Herein, the
results show the inhibition performance and the interaction site between site-specific …

The work presented herein focuses on the implementation of advanced fragmentation
techniques with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) …

Abstract Formulation studies are performed when a new pharmaceutically active ingredient
(API) of interest, such as a protein, is under development in order to find conditions for …