The endocannabinoid system (ECS), which is composed of the cannabinoid receptors types
1 and 2 (CB1 and CB2) for marijuana's psychoactive ingredient∆ 9-tetrahydrocannabinol (∆ …

Major depression (MD) is the most common psychiatric disorder, predicted to affect around
264 million people worldwide. Although the etiology of depression remains elusive, the …

Postoperative cognitive dysfunction increases mortality and morbidity in perioperative
patients and has become a major concern for patients and caregivers. Previous studies …

Background There are sex differences in addiction behaviors. To develop a pre-clinical
animal model to investigate this, the present study examined sex differences in sucrose …

Abnormalities in hippocampal synaptic plasticity contribute to the pathogenesis of post-
traumatic stress disorder (PTSD). The Wnt/β-catenin signaling pathway is critical for the …

The study aimed to explore in vivo the influence of cannabidiol (CBD) on the development of
alcohol tolerance in rats. Rats were treated with ethanol (3.0 g/kg, ip) and CBD (20 mg/kg …

Our aims were to evaluate the depression model of early maternal separation (MS)
combined with adolescent chronic unpredictable mild stress (CUMS) in female adult SD rats …

Background Our recent study demonstrated that selective aryl hydrocarbon receptor
modulators (SAhRMs), such as 1, 4-dihydroxy-2-napthoic acid (DHNA) act as …

Background Accumulative data links inflammation and immune dysregulation to the
pathophysiology of mental disorders; little is known regarding leukotrienes'(LTs) …

Animal models are essential for understanding the biological factors that contribute to drug
and alcohol addiction and discovering new pharmacotherapies to treat these disorders …