Pancreatic cancer (PC) is the most aggressive type of common cancers, and in 2014, nearly
40000 patients died from the disease in the United States. Pancreatic ductal …

Pancreatic ductal adenocarcinoma (PDA) is among the deadliest cancers in the United
States and in the world. Late diagnosis, early metastasis and lack of effective therapy are …

Pancreatic cancer is an extremely dismal malignance. Chemotherapy has been widely
applied to treat this intractable tumor. It has exclusive tumor microenvironment (TME) …

PANC-1 human pancreatic cancer cells are characterized by their ability to proliferate
aggressively under hypovascular and hypoxic conditions in the tumor microenvironment …

Human pancreatic cancer cell lines such as PANC-1 have an altered metabolism, enabiling
them to tolerate and survive under extreme conditions of nutrient starvation. The search for …

Patients with pancreatic cancer have a poor prognosis with a median survival of 4-6 mo and
a 5-year survival of less than 5%. Despite therapy with gemcitabine, patient survival does …

Desmoplasia or abundant fibrotic stroma is a typical property of most malignancies, which
has a great effect on tumorigenesis, angiogenesis, and resistance to therapy. The activated …

Biakamides A–D, novel unusually unique polyketides, were isolated from an Indonesian
marine sponge (Petrosaspongia sp.) with a constructed bioassay using PANC-1 human …

Human pancreatic tumor cells have inherent ability to tolerate nutrition starvation which
enables them to survive in the hypovascular tumor microenvironment. Discovery of agents …

Pancreatic cancer is one of the deadliest types of malignancies. A new intervention aiming
to combat pancreatic cancer is targeting its extra-ordinary ability to tolerate nutrition …