Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

Vaccines for COVID-19: a systematic review of immunogenicity, current development, and future prospects

Z Zhang, Q Shen, H Chang - Frontiers in immunology, 2022 - frontiersin.org
The persistent coronavirus disease 2019 (COVID-19), characterized by severe respiratory
syndrome, is caused by coronavirus 2 (SARS-CoV-2), and it poses a major threat to public …

CD8 T cells contribute to vaccine protection against SARS-CoV-2 in macaques

J Liu, J Yu, K McMahan, C Jacob-Dolan, X He… - Science …, 2022 - science.org
Spike-specific neutralizing antibodies (NAbs) are generally considered key correlates of
vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Maternal immune response and placental antibody transfer after COVID-19 vaccination across trimester and platforms

CG Atyeo, LL Shook, S Brigida, RM De Guzman… - Nature …, 2022 - nature.com
The availability of three COVID-19 vaccines in the United States provides an unprecedented
opportunity to examine how vaccine platforms and timing of vaccination in pregnancy impact …

A systematic review on COVID-19 vaccine strategies, their effectiveness, and issues

SS Khandker, B Godman, MI Jawad, BA Meghla… - Vaccines, 2021 - mdpi.com
COVID-19 vaccines are indispensable, with the number of cases and mortality still rising,
and currently no medicines are routinely available for reducing morbidity and mortality, apart …

[HTML][HTML] Differential immunogenicity of homologous versus heterologous boost in Ad26. COV2. S vaccine recipients

NKH Khoo, JME Lim, US Gill, R de Alwis, N Tan… - Med, 2022 - cell.com
Background Protection offered by coronavirus disease 2019 (COVID-19) vaccines wanes
over time, requiring an evaluation of different boosting strategies to revert such a trend and …

Booster with Ad26. COV2. S or Omicron-adapted vaccine enhanced immunity and efficacy against SARS-CoV-2 Omicron in macaques

L Solforosi, LMM Costes, JTBM Tolboom… - Nature …, 2023 - nature.com
Omicron spike (S) encoding vaccines as boosters, are a potential strategy to improve COVID-
19 vaccine efficacy against Omicron. Here, macaques (mostly females) previously …

Development of safe and highly protective live-attenuated SARS-CoV-2 vaccine candidates by genome recoding

J Trimpert, K Dietert, TC Firsching, N Ebert, TTN Thao… - Cell reports, 2021 - cell.com
Safe and effective vaccines are urgently needed to stop the pandemic caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We construct a series of live …

Immunity elicited by natural infection or Ad26. COV2. S vaccination protects hamsters against SARS-CoV-2 variants of concern

LH Tostanoski, J Yu, NB Mercado… - Science translational …, 2021 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern have
emerged and may pose a threat to both the efficacy of vaccines based on the original …

[HTML][HTML] The intestinal microbiota and improving the efficacy of COVID-19 vaccinations

J Chen, L Vitetta, JD Henson, S Hall - Journal of Functional Foods, 2021 - Elsevier
Most COVID-19 cases are mild or asymptomatic and recover well, suggesting that effective
immune responses ensue, which successfully eliminate SARS-CoV-2 viruses. However, a …