Troponin complex is a component of skeletal and cardiac muscle thin filaments. It consists of
three subunits—troponin I, T, and C, and it plays a crucial role in muscle activity, connecting …

During the past 5 years there has been an increasing body of literature describing the roles
cardiac myosin binding protein C (cMyBP-C) phosphorylation play in regulating cardiac …

Protein kinase D (PKD) is an evolutionarily conserved protein kinase family with structural,
enzymological, and regulatory properties different from the PKC family members. Signaling …

Oxidative stress accompanies a wide spectrum of clinically important cardiac disorders,
including ischemia/reperfusion, diabetes mellitus, and hypertensive heart disease. Although …

Background: Patients with systemic sclerosis (SSc)–associated pulmonary arterial
hypertension (PAH) have a far worse prognosis than those with idiopathic PAH (IPAH). In …

The adult heart responds to biomechanical stress and neurohormonal signaling by
hypertrophic growth, accompanied by fibrosis, diminished pump function, and activation of a …

Activation of the sarcolemmal Na+/H+ exchanger (NHE) 1 is increasingly documented as a
process involved in cardiac hypertrophy and heart failure. However, whether NHE1 …

Sarcomeric dysfunction plays a central role in reduced cardiac pump function in heart
failure. This review focuses on the alterations in sarcomeric proteins in diseased …

Troponin I (TnI) is the inhibitory subunit of the troponin complex in the sarcomeric thin
filament of striated muscle and plays a central role in the calcium regulation of contraction …

Cardiac myosin-binding protein-C (cMyBP-C) is an important regulator of cardiac
contractility, and its phosphorylation by PKA is a mechanism that contributes to increased …