While medicinal inorganic chemistry has been practised for over 5000 years, it was not until
the late 1800s when Alfred Werner published his ground-breaking research on coordination …

The platinum drugs, cisplatin, carboplatin, and oxaliplatin, prevail in the treatment of cancer,
but new platinum agents have been very slow to enter the clinic. Recently, however, there …

History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

The discovery of cisplatin (cis-Pt (NH 3) 2 Cl 2) as an antineoplastic agent has focussed
attention on the rational design of metal complexes that can be potentially used in cancer …

Since the antitumor activity of cisplatin was discovered in 1967 by Rosenberg, platinum-
based anticancer drugs have played an important role in chemotherapy in clinic …

Ever increasing unmet medical requirements of the human race and the continuous fight for
survival against variety of diseases give birth to novel molecules through research. As …

The conjugation of biologically active molecules is a powerful tool for drug discovery used to
target a variety of multifunctional diseases including cancer. Conjugated drugs can provide …

We describe a novel improved approach to the synthesis of the important and well-known
heat shock protein 70 inhibitor (HSP70), pifithrin-μ, with corresponding and previously …

Background: Cisplatin, a platinum complex discovered by Rosenberg in 1969, has long
been known as the first metal-based anticancer agent. Since then, various similar …

One of the key strategies in chemotherapy involves crosslinking the DNA strands of cancer
cells to impede their replication, with platinum (Pt) coordination compounds being a …