It is difficult to distinguish at preschool age whether a wheezing child will or will not have
asthma at school age. A prediction rule for asthma in preschool children might help to …

Asthma exacerbations are among the most frequent causes of hospitalization during
childhood, but the underlying mechanisms are poorly understood. We performed a genome …

BACKGROUND: Changes in the human microbiome have been suggested as a risk factor
for a number of lifestyle-related disorders, such as atopic diseases, possibly through a …

Background Both genetic variation at the 17q21 locus and virus-induced respiratory
wheezing illnesses are associated with the development of asthma. Our aim was to …

Asthma is believed to arise through early life aberrant immune development in response to
environmental exposures that may influence the airway microbiota. Here, we examine the …

Asthma is a chronic inflammatory disease of the airways which can have a detrimental effect
on quality of life and in extreme cases cause death. Although the majority of patients can …

Rationale: The causal direction between asthma and lung function deficit is unknown, but
important for the focus of preventive measures and research into the origins of asthma …

Background Bacteria and viruses are equally associated with the risk of acute episodes of
asthma-like symptoms in young children, suggesting antibiotics as a potential treatment for …

Background Urbanization is linked with an increased burden of asthma and atopic traits. A
putative mechanism is insufficient exposure to beneficial microbes early in life, leading to …

Rationale: The frequency of pneumonia and bronchiolitis exhibits considerable variation in
otherwise healthy children, and suspected risk factors explain only a minor proportion of the …