Besides their role in cell metabolism, mitochondria display many other functions.
Mitochondrial DNA (mtDNA), the own genome of the organelle, plays an important role in …

Mitochondria are functionally versatile organelles. In addition to their conventional role of
meeting the cell's energy requirements, mitochondria also actively regulate innate immune …

Background Mitochondrial DNA (MT-DNA) are intrinsically inflammatory nucleic acids
released by damaged solid organs. Whether circulating cell-free MT-DNA quantitation could …

Over the recent years, much has been unraveled about the pro-inflammatory properties of
various mitochondrial molecules once they are leaving the mitochondrial compartment. On …

Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by a
slow, progressive, and multifactorial degeneration of retinal ganglion cells (RGCs) and their …

The acute respiratory distress syndrome (ARDS) is a form of severe hypoxemic respiratory
failure that is characterized by inflammatory injury to the alveolar capillary barrier, with …

Abstract In 1994, the “danger model” argued that adaptive immune responses are driven
rather by molecules released upon tissue damage than by the recognition of “strange” …

Throughout more than 1.5 billion years of obligate endosymbiotic co-evolution, mitochondria
have developed not only the capacity to control distinct molecular cascades leading to cell …

Over the past few decades, research on Alzheimer's disease (AD) has focused on
pathomechanisms linked to two of the major pathological hallmarks of extracellular …

Significance: Mitochondria, vital cellular power plants to generate energy, are involved in
immune responses. Mitochondrial damage-associated molecular patterns (DAMPs) are …