The presence of barriers, such as the blood–brain barrier (BBB) and brain–tumor barrier
(BTB), limits the penetration of antineoplastic drugs into the brain, resulting in poor response …

The advent of the miniaturization approach has influenced the research trends in almost all
disciplines. Bioengineering is one of the fields benefiting from the new possibilities of …

Drug discovery and development for stroke is challenging as evidenced by few drugs that
have advanced beyond a Phase III clinical trial. Memantine is a N-methyl-d-aspartate …

The blood-brain barrier (BBB) is a semipermeable unit that serves to vascularize the central
nervous system (CNS) while tightly regulating the movement of molecules, ions, and cells …

Alzheimer's disease (AD) is to blame for about 60% of dementia cases worldwide. The blood–
brain barrier (BBB) prevents many medications for AD from having clinical therapeutic …

Sesquiterpene lactones-such as those found in chicory-are considered promising bioactive
compounds. These small molecules have shown several health benefits for various …

The blood-brain barrier (BBB) is a tightly and actively regulated vascular barrier. Answering
fundamental biological and translational questions about the BBB with currently available …

Abstract The L-Type Amino Acid transporter, LAT1 (SLC7A5), has a crucial role in mediating
amino acid uptake into the cells, thus modulating cell growth and proliferation as well as …

Alzheimer's disease (AD) is the most common neurodegenerative disorder and its
prevalence is increasing. Nowadays, very few drugs effectively reduce AD symptoms and …

The blood-brain barrier (BBB) serves as a defensive line protecting the central nervous
system, while also maintaining micro-environment homeostasis and inhibiting harmful …