The innate immune system uses multiple strategies to detect viral infections. Because all
viruses rely on host cells for their synthesis and propagation, the molecular features used to …

The innate immune system is a broad collection of critical intra‐and extra‐cellular processes
that limit the infectivity of diverse pathogens. The 2′‐5′‐oligoadenylate synthetase (OAS) …

Molecular recognition of RNA structure is key to innate immunity. The protein kinase PKR
differentiates self from non-self by recognition of molecular patterns in RNA. Certain …

The interferon-inducible protein kinase R (PKR) is a key component of host innate immunity
that restricts viral replication and propagation. As one of the four eIF2α kinases that sense …

Abstract Adenovirus (AdV)'virus-associated'RNAs (VA RNAs) are exceptionally abundant
(up to 10 8 copies/cell), heterogeneous, non-coding RNA transcripts (∼ 150–200 …

Abstract Adenovirus Virus-Associated (VA) RNAs are the first discovered viral noncoding
RNAs. By mimicking double-stranded RNAs (dsRNAs), the exceptionally abundant …

Transduction with replication-incompetent recombinant adenovirus (Ad) vectors results in a
rapid activation of innate immune responses, such as inflammatory cytokine production and …

Isothermal titration calorimetry (ITC) is a fast, accurate and label‐free method for measuring
the thermodynamics and binding affinities of molecular associations in solution. Because the …

The innate immune system offers a first line of defense by neutralizing foreign pathogens
such as bacteria, fungi, and viruses. These pathogens express molecules (RNA and …

Galluzzi L, Kepp O, Morselli E, Vitale I, Senovilla L, Pinti M, Zitvogel L, Kroemer G (INSERM,
U848; Institut Gustave Roussy; and Université Paris Sud‐XI, Paris, France; Università degli …