A virological view of innate immune recognition

A Iwasaki - Annual review of microbiology, 2012 - annualreviews.org
The innate immune system uses multiple strategies to detect viral infections. Because all
viruses rely on host cells for their synthesis and propagation, the molecular features used to …

RNA regulation of the antiviral protein 2′‐5′‐oligoadenylate synthetase

SL Schwartz, GL Conn - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
The innate immune system is a broad collection of critical intra‐and extra‐cellular processes
that limit the infectivity of diverse pathogens. The 2′‐5′‐oligoadenylate synthetase (OAS) …

Regulation of innate immunity through RNA structure and the protein kinase PKR

SR Nallagatla, R Toroney, PC Bevilacqua - Current opinion in structural …, 2011 - Elsevier
Molecular recognition of RNA structure is key to innate immunity. The protein kinase PKR
differentiates self from non-self by recognition of molecular patterns in RNA. Certain …

The search for a PKR code—differential regulation of protein kinase R activity by diverse RNA and protein regulators

C Bou-Nader, JM Gordon, FE Henderson, J Zhang - Rna, 2019 - rnajournal.cshlp.org
The interferon-inducible protein kinase R (PKR) is a key component of host innate immunity
that restricts viral replication and propagation. As one of the four eIF2α kinases that sense …

Adenovirus VA RNA: an essential pro-viral non-coding RNA

VK Vachon, GL Conn - Virus research, 2016 - Elsevier
Abstract Adenovirus (AdV)'virus-associated'RNAs (VA RNAs) are exceptionally abundant
(up to 10 8 copies/cell), heterogeneous, non-coding RNA transcripts (∼ 150–200 …

[HTML][HTML] Crystal structure of an adenovirus virus-associated RNA

IV Hood, JM Gordon, C Bou-Nader… - Nature …, 2019 - nature.com
Abstract Adenovirus Virus-Associated (VA) RNAs are the first discovered viral noncoding
RNAs. By mimicking double-stranded RNAs (dsRNAs), the exceptionally abundant …

Induction of type I interferon by adenovirus-encoded small RNAs

T Yamaguchi, K Kawabata… - Proceedings of the …, 2010 - National Acad Sciences
Transduction with replication-incompetent recombinant adenovirus (Ad) vectors results in a
rapid activation of innate immune responses, such as inflammatory cytokine production and …

Survey of the year 2008: applications of isothermal titration calorimetry

RJ Falconer, A Penkova, I Jelesarov… - Journal of molecular …, 2010 - Wiley Online Library
Isothermal titration calorimetry (ITC) is a fast, accurate and label‐free method for measuring
the thermodynamics and binding affinities of molecular associations in solution. Because the …

Viral proteins targeting host protein kinase R to evade an innate immune response: a mini review

E Dzananovic, SA McKenna… - Biotechnology and Genetic …, 2018 - Taylor & Francis
The innate immune system offers a first line of defense by neutralizing foreign pathogens
such as bacteria, fungi, and viruses. These pathogens express molecules (RNA and …

Viral strategies for the evasion of immunogenic cell death

L Galluzzi, O Kepp, E Morselli, I Vitale… - Journal of internal …, 2010 - Wiley Online Library
Galluzzi L, Kepp O, Morselli E, Vitale I, Senovilla L, Pinti M, Zitvogel L, Kroemer G (INSERM,
U848; Institut Gustave Roussy; and Université Paris Sud‐XI, Paris, France; Università degli …