Oxidative stress and inflammation are two critical pathological processes of cerebral
ischemia-reperfusion injury. Myeloperoxidase (MPO) is a critical inflammatory enzyme and …

The epidemic of pneumonia (COVID-19) caused by novel coronavirus (SARS-CoV-2)
infection has been listed as a public health emergency of international concern by the World …

Ischemic stroke is a challenging disease with high mortality and disability rates, causing a
great economic and social burden worldwide. During ischemic stroke, ionic imbalance and …

Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

Herbal medicine (HM) has made a major contribution to the drug discovery process with
regard to identifying products compounds. Currently, more attention has been focused on …

Traumatic brain injury (TBI) has become a leading cause of mortality, morbidity and disability
worldwide. Hydroxysafflor yellow A (HSYA) is effective in treating TBI, but the potential …

Natural product (NP) has a long history in promoting modern drug discovery, which has
derived or inspired a large number of currently prescribed drugs. Recently, the NPs have …

Peroxynitrite (ONOO−) and high mobility group box 1 protein (HMGB1) are important
cytotoxic factors contributing to cerebral ischemia-reperfusion injury. However, the roles of …

Tissue plasminogen activator (t-PA) has a restrictive therapeutic window within 4.5 h after
ischemic stroke with the risk of hemorrhagic transformation (HT) and neurotoxicity when it is …

Stroke remains one of the most devastating and challenging neurological diseases
worldwide. Inflammation, as well as oxidative stress is one of the main contributors to post …