The apelin receptor (APJ; gene symbol APLNR) is a member of the G protein-coupled
receptor gene family. Neural gene expression patterns of APJ, and its cognate ligand apelin …

It is well established that pubertal activation of the reproductive axis and maintenance of
fertility are critically dependent on the magnitude of body energy reserves and the metabolic …

Whole-genome sequencing data allow detection of copy number variation (CNV) at high
resolution. However, estimation based on read coverage along the genome suffers from …

Sertoli–Leydig cell tumors are characterized by the presence of somatic DICER1 hotspot
mutations. In this study, we sought to define the association between DICER1 hotspot …

Reproduction is an energy demanding function and only take place in case of sufficient
available energy status in mammals. Metabolic diseases such as anorexia nervosa are …

Metformin has been treated for diabetes (type 2). Nowadays, this compound is frequently
found in ambient water, influent/effluent of a wastewater treatment plant. To evaluate the …

AMP-activated protein kinase AMPK regulates cellular energy by controlling metabolism
through the inhibition of anabolic pathways and the simultaneous stimulation of catabolic …

In rodents and humans, testicular cells, similar to other mammalian cells, are supported by
actin-, microtubule (MT)-and intermediate filament-based cytoskeletons. Although the …

From C. elegans to mammals (including humans), nutrition and energy metabolism
significantly influence reproduction. At the cellular level, some detectors of energy status …

The mammalian target of rapamycin (Mtor) gene encodes a serine/threonine kinase that acts
as a master regulator of processes as diverse as cell growth, protein synthesis, cytoskeleton …