Hydrogels for protein delivery

T Vermonden, R Censi, WE Hennink - Chemical reviews, 2012 - ACS Publications
Importantly, with the advent of hybridoma and recombinant DNA technologies, the limitations
associated with the extraction and purification of pharmaceutical proteins from animal …

Injectable hydrogels for sustained release of therapeutic agents

T Thambi, Y Li, DS Lee - Journal of Controlled Release, 2017 - Elsevier
Hydrogels are natural or synthetic polymer networks that exhibit high water absorbent
capacities and have been used as scaffolds for tissue engineering or as delivery carriers for …

In situ gelling pH-and temperature-sensitive biodegradable block copolymer hydrogels for drug delivery

NK Singh, DS Lee - Journal of Controlled Release, 2014 - Elsevier
Stimuli-sensitive injectable polymeric hydrogels have been extensively investigated during
the past decade as bioactive agent delivery vehicles and for tissue engineering applications …

Injectable polymeric hydrogels for the delivery of therapeutic agents: A review

QV Nguyen, JH Park, DS Lee - European Polymer Journal, 2015 - Elsevier
Since drug delivery systems have become one of the most promising areas of human health
related research, the applications of biomaterials such as hydrogels have been widely …

Bioactive factor delivery strategies from engineered polymer hydrogels for therapeutic medicine

MK Nguyen, E Alsberg - Progress in polymer science, 2014 - Elsevier
Polymer hydrogels have been widely explored as therapeutic delivery matrices because of
their ability to present sustained, localized and controlled release of bioactive factors …

Injectable block copolymer hydrogels: achievements and future challenges for biomedical applications

CT Huynh, MK Nguyen, DS Lee - Macromolecules, 2011 - ACS Publications
In the past two decades, physical polymeric hydrogels have been extensively explored for
biomedical applications, such as drug delivery and tissue engineering. These hydrogels …

Logic‐based delivery of site‐specifically modified proteins from environmentally responsive hydrogel biomaterials

PM Gawade, JA Shadish, BA Badeau… - Advanced …, 2019 - Wiley Online Library
The controlled presentation of proteins from and within materials remains of significant
interest for many bioengineering applications. Though “smart” platforms offer control over …

Biodegradable, p H‐R esponsive Carboxymethyl Cellulose/P oly (A crylic Acid) Hydrogels for Oral Insulin Delivery

X Gao, Y Cao, X Song, Z Zhang… - Macromolecular …, 2014 - Wiley Online Library
Biodegradable and pH‐responsive carboxymethyl cellulose/poly (acrylic acid) hybrid
hydrogels are synthesized. The hydrogels deswell in acidic artificial gastric fluid (AGF) but …

Recent strategies to develop pH-sensitive injectable hydrogels

T Thambi, JM Jung, DS Lee - Biomaterials Science, 2023 - pubs.rsc.org
“Smart” biomaterials that are responsive to pathological abnormalities are an appealing
class of therapeutic platforms for the development of personalized medications. The …

In situ forming injectable thermoresponsive hydrogels for controlled delivery of biomacromolecules

K Dutta, R Das, J Ling, RM Monibas… - ACS …, 2020 - ACS Publications
Due to their relatively large molecular sizes and delicate nature, biologic drugs such as
peptides, proteins, and antibodies often require high and repeated dosing, which can cause …