Time-resolved single-cell RNA-seq using metabolic RNA labelling
Single-cell RNA genomics technologies are revolutionizing biomedical science by profiling
single cells with unprecedented resolution, providing fundamental insights into the role of …
single cells with unprecedented resolution, providing fundamental insights into the role of …
Pathophysiology of psoriasis: A review
K Yamanaka, O Yamamoto… - The Journal of …, 2021 - Wiley Online Library
Psoriasis is a complex chronic inflammatory skin disease caused by the dynamic interplay
between multiple genetic risk foci, environmental risk factors, and excessive immunological …
between multiple genetic risk foci, environmental risk factors, and excessive immunological …
Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2
Measurement of the location of molecules in tissues is essential for understanding tissue
formation and function. Previously, we developed Slide-seq, a technology that enables …
formation and function. Previously, we developed Slide-seq, a technology that enables …
A single-cell atlas of the peripheral immune response in patients with severe COVID-19
There is an urgent need to better understand the pathophysiology of Coronavirus disease
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …
2019 (COVID-19), the global pandemic caused by SARS-CoV-2, which has infected more …
Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19
SARS-CoV-2 infection can cause severe respiratory COVID-19. However, many individuals
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
present with isolated upper respiratory symptoms, suggesting potential to constrain viral …
Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …
SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is detected in specific cell subsets across tissues
There is pressing urgency to understand the pathogenesis of the severe acute respiratory
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …
syndrome coronavirus clade 2 (SARS-CoV-2), which causes the disease COVID-19. SARS …
Single-cell analyses of colon and blood reveal distinct immune cell signatures of ulcerative colitis and Crohn's disease
Background & Aims Studies are needed to determine the mechanisms of mucosal
dysregulation in patients with inflammatory bowel diseases (IBDs) and differences in …
dysregulation in patients with inflammatory bowel diseases (IBDs) and differences in …
PI3Kβ controls immune evasion in PTEN-deficient breast tumours
JS Bergholz, Q Wang, Q Wang, M Ramseier… - Nature, 2023 - nature.com
Loss of the PTEN tumour suppressor is one of the most common oncogenic drivers across
all cancer types. PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform …
all cancer types. PTEN is the major negative regulator of PI3K signalling. The PI3Kβ isoform …
Lymph nodes are innervated by a unique population of sensory neurons with immunomodulatory potential
S Huang, CGK Ziegler, J Austin, N Mannoun… - Cell, 2021 - cell.com
Barrier tissue immune responses are regulated in part by nociceptors. Nociceptor ablation
alters local immune responses at peripheral sites and within draining lymph nodes (LNs) …
alters local immune responses at peripheral sites and within draining lymph nodes (LNs) …