The accumulation of proteinaceous inclusions in the brain is a common feature among
neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease (PD), and …

Parkinson's disease (PD) is a progressive neurodegenerative disease where dopaminergic
neurons in the substantia nigra are lost, resulting in a decrease in striatal dopamine and …

APOE4 is a strong genetic risk factor for Alzheimer's disease and Dementia with Lewy
bodies; however, how its expression impacts pathogenic pathways in a human-relevant …

Abstract α-Synuclein (αS) is a presynaptic protein whose aggregates are considered as a
hallmark of Parkinson's disease (PD). Although its physiological function is still under …

The pathological hallmark of synucleinopathies, including Parkinson's disease (PD), is the
aggregation of α-synuclein (α-Syn) protein. Even so, tau protein pathology is abundantly …

Organelles juxtaposition has been detected for decades, although only recently gained
importance due to a pivotal role in the regulation of cellular processes dependent on …

Brain iron accumulation constitutes a pathognomonic indicator in several
neurodegenerative disorders. Metal accumulation associated with dopaminergic neuronal …

Parkinson's disease (PD) is a neurodegenerative disorder that affects over 10 million aging
people worldwide. This condition is characterized by the degeneration of dopaminergic …

Recent studies have implicated synucleins in several reactions during the biosynthesis of
lipids and fatty acids in addition to their recognised role in membrane lipid binding and …

Brain iron accumulation constitutes a pathognomonic indicator in several
neurodegenerative disorders. Metal accumulation associated with dopaminergic neuronal …