Addiction is a disease in which, after a period of recreational use, a subset of individuals
develops compulsive use that does not stop even in light of major negative consequences …

In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …

Dynamic interactions of neurons and glia in the ventral midbrain mediate reward and
addiction behavior. We studied gene expression in 212,713 ventral midbrain single nuclei …

Studies over the past several decades have identified numerous epigenetic mechanisms
associated with pathological states in psychiatric and neurological disease. Until recently …

Epigenome editing is a promising technology, potentially allowing the stable reprogramming
of gene expression profiles without alteration of the DNA sequence. Targeted DNA …

We explore how functional genomics approaches that integrate datasets from human and
non-human model systems can improve our understanding of the effect of gene …

Substance use disorders (SUDs) are chronic brain diseases characterized by transitions
from recreational to compulsive drug use and aberrant drug craving that persists for months …

Addiction is a chronically relapsing neuropsychiatric disease that occurs in some, but not all,
individuals who use substances of abuse. Relatively little is known about the mechanisms …

Substance use disorders are highly prevalent and continue to be one of the leading causes
of disability in the world. Notably, not all people who use addictive drugs develop a …

Delineating the pathophysiology of psychiatric disorders has been extremely challenging
but technological advances in recent decades have facilitated a deeper interrogation of …