Cardiomyocytes are subjected to the intense mechanical stress and metabolic demands of
the beating heart. It is unclear whether these cells, which are long-lived and rarely renew …

We describe pLink 2, a search engine with higher speed and reliability for proteome-scale
identification of cross-linked peptides. With a two-stage open search strategy facilitated by …

Like normal hematopoietic stem cells, leukemic stem cells depend on their bone marrow
(BM) microenvironment for survival, but the underlying mechanisms remain largely …

Interaction of T cell with antigen-bearing dendritic cells (DC) results in T cell activation, but
whether this interaction has physiological consequences on DC function is largely …

Birth presents a metabolic challenge to cardiomyocytes as they reshape fuel preference
from glucose to fatty acids for postnatal energy production,. This adaptation is triggered in …

Cardiovascular disease (CVD) is the leading cause of mortality in the world, with most CVD-
related deaths resulting from myocardial infarction or stroke. The main underlying cause of …

The transcriptional regulator YAP orchestrates many cellular functions, including tissue
homeostasis, organ growth control, and tumorigenesis. Mechanical stimuli are a key input to …

Better understanding on interactions between SARS‐CoV‐2 and host cells should help to
identify host factors that may be targetable to combat infection and COVID‐19 pathology. To …

Pathological vascular remodeling is the underlying cause of atherosclerosis and abdominal
aortic aneurysm (AAA). Here, we analyzed the role of galectin-1 (Gal-1), a β-galactoside …

Background Imaging of subclinical atherosclerosis improves cardiovascular risk prediction
on top of traditional risk factors. However, cardiovascular imaging is not universally …