Protein function in precision medicine: deep understanding with machine learning
Precision medicine and personalized health efforts propose leveraging complex molecular,
medical and family history, along with other types of personal data toward better life. We …
medical and family history, along with other types of personal data toward better life. We …
Analysis of protein function and its prediction from amino acid sequence
WT Clark, P Radivojac - Proteins: Structure, Function, and …, 2011 - Wiley Online Library
Understanding protein function is one of the keys to understanding life at the molecular
level. It is also important in the context of human disease because many conditions arise as …
level. It is also important in the context of human disease because many conditions arise as …
When loss-of-function is loss of function: assessing mutational signatures and impact of loss-of-function genetic variants
Motivation Loss-of-function genetic variants are frequently associated with severe clinical
phenotypes, yet many are present in the genomes of healthy individuals. The available …
phenotypes, yet many are present in the genomes of healthy individuals. The available …
Loss of post-translational modification sites in disease
S Li, LM Iakoucheva, SD MOONEY… - Pacific Symposium on …, 2010 - pmc.ncbi.nlm.nih.gov
Understanding and predicting molecular cause of disease is one of the major challenges for
biology and medicine. One particular area of interest continues to be computational …
biology and medicine. One particular area of interest continues to be computational …
Chapter 15: disease gene prioritization
Y Bromberg - PLoS computational biology, 2013 - journals.plos.org
Disease-causing aberrations in the normal function of a gene define that gene as a disease
gene. Proving a causal link between a gene and a disease experimentally is expensive and …
gene. Proving a causal link between a gene and a disease experimentally is expensive and …
OrthoDisease: tracking disease gene orthologs across 100 species
K Forslund, F Schreiber, N Thanintorn… - Briefings in …, 2011 - academic.oup.com
Orthology is one of the most important tools available to modern biology, as it allows making
inferences from easily studied model systems to much less tractable systems of interest …
inferences from easily studied model systems to much less tractable systems of interest …
Graphlet kernels for prediction of functional residues in protein structures
We introduce a novel graph-based kernel method for annotating functional residues in
protein structures. A structure is first modeled as a protein contact graph, where nodes …
protein structures. A structure is first modeled as a protein contact graph, where nodes …
Approximate subgraph matching-based literature mining for biomedical events and relations
The biomedical text mining community has focused on developing techniques to
automatically extract important relations between biological components and semantic …
automatically extract important relations between biological components and semantic …
Mining large heterogeneous data sets in drug discovery
DJ Wild - Expert Opinion on Drug Discovery, 2009 - Taylor & Francis
Background: Increasingly, effective drug discovery involves the searching and data mining
of large volumes of information from many sources covering the domains of chemistry …
of large volumes of information from many sources covering the domains of chemistry …
Analysis of AML genes in dysregulated molecular networks
Background Identifying disease causing genes and understanding their molecular
mechanisms are essential to developing effective therapeutics. Thus, several computational …
mechanisms are essential to developing effective therapeutics. Thus, several computational …