Phages differ substantially in the bacterial hosts that they infect. Their host range is
determined by the specific structures that they use to target bacterial cells. Tailed phages …

Phage T4 has provided countless contributions to the paradigms of genetics and
biochemistry. Its complete genome sequence of 168,903 bp encodes about 300 gene …

Many missense substitutions are identified in single nucleotide polymorphism (SNP) data
and large-scale random mutagenesis projects. Each amino acid substitution potentially …

Technological advances in cryo-EM in recent years have given rise to detailed atomic
structures of bacteriophage tail tubes—a class of filamentous protein assemblies that could …

Abstract Salmonella Enteritidis, Salmonella Typhimurium, and Escherichia coli O157: H7 are
the most important foodborne pathogens, causing serious food poisoning outbreaks …

Bacteriophage T4 has a very efficient mechanism for infecting cells. The key component of
this process is the baseplate, located at the end of the phage tail, which regulates the …

With the increasing global threat of antibiotic resistance, there is an urgent need to develop
new effective therapies to tackle antibiotic-resistant bacterial infections. Bacteriophage …

Resistance rates are increasing among several problematic Gram-negative pathogens, a
fact that has encouraged the development of new antimicrobial agents. This paper …

Contractile tail bacteriophages, or myobacteriophages, use a sophisticated biomolecular
structure to inject their genome into the bacterial host cell. This structure consists of a …

Viruses are fundamental to ecosystems ranging from oceans to humans, yet our ability to
study them is bottlenecked by the lack of ecologically relevant isolates, resulting in …